Depression and anxiety during pregnancy and the postpartum period in women with epilepsy: A review of frequency, risks and recommendations for treatment

Seizure : the Journal of the British Epilepsy Association
Marte H BjørkN E Gilhus

Abstract

To review available data and provide treatment recommendations concerning peripartum depression, anxiety and fear of birth in women with epilepsy (WWE). The PubMed, the LactMed, the DART and the Cochrane database were searched for original articles concerning psychiatric disease in the peripartum period in WWE. Point prevalence of depression from 2nd trimester to 6 months postpartum ranged from 16 to 35% in women with epilepsy compared to 9-12% in controls. The highest estimates were found early in pregnancy and in the perinatal period. Anxiety symptoms 6 months postpartum were reported by 10 and 5%, respectively. Fear of birth symptoms were increased in primiparous WWE compared to controls. Previous psychiatric disease, sexual/physical abuse, antiepileptic drug (AED) polytherapy, and high seizure frequency emerged as strong risk factors. Depressed WWE rarely used antidepressive medication during pregnancy. No evidence was available concerning treatment effects or impact on the developing child. Peripartum depression is frequent in WWE and seldom medically treated. Health personnel should screen WWE for psychiatric disease and risk factors during pre-pregnancy planning, pregnancy and postpartum follow up. Treatment decisions sh...Continue Reading

References

Jul 14, 1999·Journal of Affective Disorders·K D JenningsM Elmore
Oct 3, 1999·Child Abuse & Neglect·S P CadzowJ A Fraser
Oct 8, 1999·Seizure : the Journal of the British Epilepsy Association·C Fox, T Betts
Jan 11, 2003·Journal of Psychosomatic Obstetrics and Gynaecology·V Geissbuehler, J Eberhard
Oct 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·Margaret Oates
Sep 8, 2004·Archives of General Psychiatry·Atif RahmanRichard Harrington
Apr 28, 2005·Expert Review of Neurotherapeutics·Marco MulaMichael R Trimble
Aug 2, 2005·Epilepsy & Behavior : E&B·Stefan BeyenburgMarkus Reuber
Jul 25, 2006·Epilepsy & Behavior : E&B·Katherine TurnerRaffaele Canger
Dec 7, 2006·JAMA : the Journal of the American Medical Association·Trine Munk-OlsenPreben Bo Mortensen
Aug 9, 2007·Seizure : the Journal of the British Epilepsy Association·Jan BagshawBrian Chappell
Oct 24, 2007·British Journal of Clinical Pharmacology·Marian K BakkerLolkje T W de Jong van den Berg
Nov 16, 2007·Journal of Affective Disorders·Purificación NavarroRocío Martín-Santos
Dec 17, 2008·Psychosomatic Medicine·Eric L Anderson, Irving M Reti
Jan 15, 2009·Epilepsia·Katherine TurnerMaria Paola Canevini
Jan 9, 2009·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Laura J DietzMichael Marshal
Oct 27, 2009·Epilepsy & Behavior : E&B·Melanie GalantiZachary N Stowe
Nov 6, 2010·Clinical Child and Family Psychology Review·Sherryl H GoodmanDevin Heyward
Feb 3, 2012·Current Women's Health Reviews·Jan Øystein Berle, Olav Spigset
Feb 12, 2013·Annual Review of Clinical Psychology·Michael W O'Hara, Jennifer E McCabe
May 9, 2013·Epilepsy & Behavior : E&B·Prachi Mehndiratta, Martha Sajatovic
Nov 5, 2013·Seizure : the Journal of the British Epilepsy Association·Kanako AbeHiroyuki Yoshikawa
Nov 12, 2013·Best Practice & Research. Clinical Obstetrics & Gynaecology·Shona Ray, Zachary N Stowe
Mar 22, 2014·Current Neurology and Neuroscience Reports·Heidi M Munger Clary
Apr 15, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·S SkurtveitM Handal
Aug 15, 2014·Journal of Women's Health·Wayne KatonAmelia Gavin
Aug 16, 2014·Journal of Psychosomatic Obstetrics and Gynaecology·Nancy VerreaultSamir Khalifé

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Citations

Aug 12, 2016·Epilepsy & Behavior : E&B·Simone Frizell ReiterNils Erik Gilhus
Feb 24, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Neda RazazK S Joseph
Sep 16, 2019·Seizure : the Journal of the British Epilepsy Association·Sonia MenonRobert Colebunders
Dec 31, 2020·Acta Neurologica Scandinavica·Frank J E VajdaMervyn J Eadie

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