Depression and anxiety in women during pregnancy and neonatal outcome: data from the EDEN mother-child cohort

Early Human Development
Gladys IbanezEDEN Mother–Child Cohort Study Group

Abstract

According to the World Health Organization, mental health disorders are the leading causes of disease burden in women from 15 to 44 years. These conditions in pregnant women may affect the offspring. To analyze the relation between depression and anxiety of pregnant women and neonatal outcomes including gestational age and birthweight. Observational cohort study. 2002 women recruited before the 20th gestational week. Gestational age at delivery in completed weeks of amenorrhea and preterm delivery defined as birth before 37 completed weeks of gestation. Spontaneous preterm birth (PB) defined as either spontaneous preterm labor or preterm premature rupture of the membranes. Medically indicated preterm delivery defined as delivery that begins by induction or cesarean section. Birthweight as a continuous variable and centiles of the customized fetal weight norms for the French population. From the 1719 women included in the study, 7.9% (n=135) were classified as "anxious", 11.8% (n=203) as "depressed", 13.2% (n=227) as "depressed and anxious". After adjusting for potential confounders, depression combined with anxiety during pregnancy increased the risk of spontaneous PB (Odds Ratio: 2.46 [1.22-4.94]), but did not influence medica...Continue Reading

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