Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Jessica Ezzell HunterStephanie L Sherman

Abstract

The fragile X mental retardation gene, FMR1, contains a polymorphic CGG repeat in the 5'-untranslated region of exon 1. Once unstable, this repeat is capable of expansion across generations. Women who carry a premutation allele (55-199 repeats) are at risk of passing on a full mutation allele (>200 repeats) to their offspring. A full mutation leads to the most common form of inherited intellectual disability, fragile X syndrome (FXS). Mounting evidence suggests that premutation carriers may be vulnerable to symptoms of anxiety and depression. The goal of this study was to test the hypothesis that among women who carry a premutation, the stress of raising a child with FXS would be moderated by genetic factors influencing endogenous cortisol responses, which could in turn modulate anxiety and depression symptoms. To this end, we genotyped single nucleotide polymorphisms (SNPs) at the corticotrophin releasing hormone receptor 1 locus (CRHR1) in 460 women. Participants completed self-report questionnaires assessing symptoms of depression [Centers for Epidemiological Studies Depression Scale (CESD)], anxiety [State-Trait Anxiety Inventory (STAI) and Social Phobia and Anxiety Inventory (SPAI)], and mood [Positive and Negative Affect ...Continue Reading

References

Sep 1, 1992·Human Molecular Genetics·J S SutcliffeS T Warren
Jul 15, 1994·American Journal of Medical Genetics·W E SobeskyR J Hagerman
Aug 9, 1996·American Journal of Medical Genetics·K L MeadowsS L Sherman
Jun 2, 1998·American Journal of Mental Retardation : AJMR·J E RiddleR J Hagerman
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Dec 18, 2001·American Journal of Medical Genetics·C JohnstonA Reiss
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Jan 30, 2004·JAMA : the Journal of the American Medical Association·Sébastien JacquemontPaul J Hagerman
Apr 10, 2004·American Journal of Mental Retardation : AJMR·Leonard AbbedutoMelissa M Murphy
Dec 21, 2004·Human Reproduction·A K SullivanS L Sherman
Feb 26, 2005·Nucleic Acids Research·Mathias EhrichDirk van den Boom
Sep 27, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·David HesslRandi J Hagerman
Oct 26, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephanie ShermanDeborah A Driscoll
Nov 15, 2006·Journal of Intellectual Disability Research : JIDR·P LewisG Orsmond
Feb 3, 2007·American Journal of Human Genetics·Ping-I LinEden R Martin
Mar 10, 2007·Annals of the New York Academy of Sciences·Russell D Romeo, Bruce S McEwen
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Cary S KoganKim M Cornish
Feb 6, 2008·Archives of General Psychiatry·Rebekah G BradleyKerry J Ressler
Feb 13, 2008·American Journal of Medical Genetics. Part a·Donald B BaileyDeborah Hatton
Feb 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Alice M GregoryThalia C Eley
Mar 19, 2008·American Journal of Medical Genetics. Part a·Sarah M CoffeyRandi J Hagerman
Jun 17, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jane E RobertsRobert N Golden
Jun 24, 2008·American Journal of Medical Genetics. Part a·Donald B BaileyDavid B Holiday
Jul 8, 2008·Psychoneuroendocrinology·Christine HeimCharles B Nemeroff
Jul 17, 2008·Psychiatric Genetics·Laia Rodriguez-RevengaMontserrat Milà
Mar 7, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jessica Ezzell HunterStephanie L Sherman
Apr 16, 2009·European Journal of Human Genetics : EJHG·Laia Rodriguez-RevengaMontserrat Milà
May 6, 2009·Journal of Health and Social Behavior·Marsha Mailick SeltzerJulie Lounds Taylor
Nov 6, 2009·Journal of Autism and Developmental Disorders·Marsha Mailick SeltzerRobert S Stawski
Jan 12, 2010·Clinical Genetics·J E HunterS L Sherman
Sep 8, 2010·The Journal of Clinical Psychiatry·James A BourgeoisRandi J Hagerman
Mar 29, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Colin G DeYoungFred A Rogosch
Dec 14, 2011·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Marsha Mailick SeltzerDavid Almeida
Jan 24, 2012·American Journal on Intellectual and Developmental Disabilities·Leann E SmithJan S Greenberg

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Citations

Aug 14, 2013·American Journal on Intellectual and Developmental Disabilities·Kruti Acharya, Abigail Schindler
Sep 12, 2015·Intractable & Rare Diseases Research·Tri Indah WinarniRandi J Hagerman
Sep 5, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Heather A KennaNatalie L Rasgon
Jul 16, 2015·Journal of Genetic Counseling·Whitney EspinelStephanie Sherman
Aug 12, 2014·Journal of Affective Disorders·Sally França Lacerda-PinheiroBianca Alves Vieira Bianco
Aug 20, 2014·Journal of Neurodevelopmental Disorders·Jim GrigsbyJin-Chen Yang
Sep 13, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Amy GossettDavid Hessl
Apr 14, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marsha MailickPaul J Rathouz
Aug 7, 2014·Journal of Neurodevelopmental Disorders·Anne C WheelerRandi Hagerman
Jan 31, 2020·Journal of Genetic Counseling·Liana SmolichStephanie L Sherman
May 5, 2017·Journal of Neurodevelopmental Disorders·Jessica KlusekJane E Roberts
Sep 13, 2017·Journal of Intellectual Disability Research : JIDR·E P LowellJ E Roberts
Jun 2, 2020·Frontiers in Pediatrics·Marsha R MailickMurray H Brilliant
Oct 30, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Claudine M KraanKim M Cornish
Jun 16, 2017·Clinical Genetics·M MilaL Rodriguez-Revenga

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