Depression and cognitive impairment in newly diagnosed systemic lupus erythematosus

The Journal of Rheumatology
Michelle PetriR L Brey

Abstract

Cognitive impairment is present in 80% of patients with systemic lupus erythematosus (SLE) 10 years after diagnosis. The natural history of cognitive dysfunction in newly diagnosed SLE is unknown. We examined the association of depression and cognitive performance in newly diagnosed SLE. A multicenter cohort of 111 patients newly diagnosed (within 9 months) with SLE underwent cognitive function testing using an automated battery [Automated Neuropsychological Assessment Metrics (ANAM)] with 9 subtests. Depression was measured using the Calgary Depression Scale (CDS). The patient cohort was 97.3% female, 55.9% white, 15.3% African American, 20.7% Hispanic, mean age 37.8 years, mean education 15.2 years. CDS score ranged from 0 to 18 (mean 5.0 ± 4.6). CDS score did not differ by age, sex, ethnicity, or prednisone dose. Higher Krupp Fatigue Severity Scale scores and presence of fibromyalgia were significantly associated with higher CDS score (p < 0.001; p = 0.006, respectively). Depressed patients, defined by a CDS score > 6, had significantly poorer performance on 5 ANAM throughput measures: code substitution (p = 0.03), continuous performance (p = 0.02), matching-to-sample (p = 0.04), simple reaction time (p = 0.02), and the Ster...Continue Reading

References

Mar 1, 1992·Schizophrenia Research·D AddingtonJ Joyce
Jul 1, 1990·Schizophrenia Research·D AddingtonB Schissel
Aug 1, 1987·Journal of Clinical and Experimental Neuropsychology·S D DenburgJ A Denburg
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1994·Scandinavian Journal of Rheumatology·G L Iverson, K W Anderson
Feb 1, 1994·Schizophrenia Research·D AddingtonE Maticka-Tyndale
Mar 1, 1993·Psychosomatic Medicine·E M Wekking
May 1, 1996·Schizophrenia Research·A A CollinsK Birkett
Jan 1, 1997·Biological Psychiatry·J C Soares, J J Mann
Jan 1, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C HanckM V Singer
Jun 5, 2002·Lupus·N A DayalD A Isenberg
Aug 2, 2003·Biological Psychiatry·Yvette I Sheline
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jun 21, 2005·International Journal of Clinical Practice·A Farzaneh-Far, M J Roman
Dec 16, 2005·The New England Journal of Medicine·Michelle PetriUNKNOWN OC-SELENA Trial
Jul 27, 2006·Arthritis and Rheumatism·Melanie J HarrisonMichael D Lockshin
Dec 6, 2006·Comprehensive Psychiatry·Fabiano G NeryFrancisco Lotufo Neto
Mar 14, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Joshua ChodoshArun S Karlamangla
May 17, 2007·Arthritis Research & Therapy·Elizabeth KozoraSterling West
Sep 18, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·E HarboeR Omdal
Dec 14, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fabiano G NeryFrancisco Lotufo Neto

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Citations

Sep 13, 2011·Journal of Neurology·Maria B Lauvsnes, Roald Omdal
Jul 28, 2013·Current Rheumatology Reports·Monthida Fangtham, Michelle Petri
Apr 13, 2013·Journal of Autoimmunity·Jing WenChaim Putterman
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Jan 11, 2013·Arthritis Research & Therapy·Aisha Lateef, Michelle Petri
May 6, 2014·La Presse médicale·Gamal ChehabMatthias Schneider
Sep 4, 2014·Autoimmunity Reviews·Hélène Jeltsch-David, Sylviane Muller
Apr 11, 2015·Lupus Science & Medicine·Meggan MackayDavid Eidelberg
Apr 5, 2011·Seminars in Arthritis and Rheumatism·Michelle PetriKathryn A Carson
Aug 29, 2013·Arthritis and Rheumatism·Maria B LauvsnesRoald Omdal
Sep 14, 2016·Health and Quality of Life Outcomes·José-Antonio López-PinaKenneth A Wallston
Oct 24, 2015·Trends in Immunology·Lior BrimbergBetty Diamond
Sep 19, 2016·Autoimmunity Reviews·Cécile M YelnikSimone Appenzeller
Jul 1, 2016·Clinical Rheumatology·Gaurav GulatiMichael E Luggen
Jun 10, 2011·Acta Neurologica Scandinavica·B M SegalK L Moser
Aug 17, 2014·The Journal of Rheumatology·Xiangyang HuangMichelle Petri
Sep 27, 2018·Current Rheumatology Reviews·Andrew KwanZahi Touma
Jun 28, 2019·Health Care for Women International·Hsuan-Man HungChung-Hey Chen
Dec 21, 2012·Current Opinion in Neurology·Fred Rincon, Clinton B Wright
Aug 14, 2019·The Journal of International Medical Research·Shuo LiFuling Yan
May 20, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·S TiosanoD Amital
Jan 20, 2019·Nature Reviews. Rheumatology·Noa SchwartzChaim Putterman
Mar 17, 2019·American Journal of Clinical Dermatology·Jennifer HongCristina Drenkard
Jan 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Xinhua ZhouMaggie Pui Man Hoi

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