Depression and hypomania symptoms are associated with high dose corticosteroids treatment for MS relapses

Journal of Affective Disorders
Sarah Anne MorrowSandra Ulch

Abstract

Psychiatric side effects are known to occur with low dose corticosteroids. Standard of care for Multiple Sclerosis (MS) relapses is high dose corticosteroids (HDC), at least 1g/day for 3-5 days, and yet the relationship between this treatment and mood is not known. We sought to determine the frequency and potential predictors of (hypo)manic and depressive symptoms with HDC treatment for MS relapses. Consecutive MS subjects requiring HDC treatment were identified. The Mood Disorders Questionnaire (MDQ) and the Beck Depression Inventory-Fast Screen (BDIFS) were administered for (hypo)manic and depressive symptoms, respectively, prior to HDC, 3 days and one month post-HDC. Eighty eight subjects completed the study. At relapse diagnosis, the mean BDIFS score was 4.2 (SD 3.1); the mean number of (hypo)manic symptoms endorsed on the MDQ was 4.3 (SD 3.5). Three days after completing HDC, 22.5% had an increase on the BDIFS and 38.2% endorsed more symptoms on the MDQ. A history of depression (p=0.006) and low reported quality of life (p=0.029) predicted an increase on the MDQ; the odds of an increase in (hypo)manic symptoms was 5.6 times higher with a history of any psychiatric disease/substance abuse (p=0.005). No predictors for worsen...Continue Reading

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Citations

Jul 7, 2017·International Review of Psychiatry·Scott B PattenMauro G Carta
Aug 8, 2019·European Archives of Psychiatry and Clinical Neuroscience·Florence Thibaut
Aug 18, 2020·Expert Review of Neurotherapeutics·Scott B Patten
Apr 21, 2017·Frontiers in Neurology·Elizabeth A MillsYang Mao-Draayer
Nov 18, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Emily M SchorrMandip S Dhamoon

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