Depression and Risk for Diabetes: A Meta-Analysis

Canadian Journal of Diabetes
Min YuLe Fang

Abstract

Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes. We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test. As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25-1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18-1.47). Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.

References

Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·L A PalinkasD L Wingard
Sep 1, 1988·Diabetes/metabolism Reviews·P Björntorp
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 1, 1997·Social Psychiatry and Psychiatric Epidemiology·U RajalaS L Kivelä
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Jul 2, 1999·Diabetes Care·N KawakamiH Ishibashi
Sep 15, 2001·The New England Journal of Medicine·F B HuW C Willett
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Mar 20, 2003·Current Diabetes Reports·Michael D Harris
Jun 6, 2003·Diabetes/metabolism Research and Reviews·Sharon H SaydahMaureen I Harris
Jun 28, 2003·Diabetes·Bruce B DuncanUNKNOWN Atherosclerosis Risk in Communities Study
Dec 25, 2003·Diabetes Care·Cassandra ArroyoJoAnn Manson
Jan 30, 2004·Diabetes Care·Sherita Hill GoldenUNKNOWN Atherosclerosis Risk in Communities study
Jun 19, 2004·Journal of Psychiatric Research·Lars Vedel KessingPer Kragh Andersen
Jul 31, 2004·Acta Psychiatrica Scandinavica·M van den AkkerF Buntinx
Oct 23, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·L A PalinkasE Barrett-Connor
Nov 25, 2004·Diabetes Care·Susan A Everson-RoseKaren A Matthews
Apr 28, 2005·Diabetes Care·Lauren C BrownJeffrey A Johnson
Aug 27, 2005·International Journal of Epidemiology·Siobhan C MatyGeorge A Kaplan
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
May 2, 2007·Psychosomatic Medicine·Mirjam J KnolHuibert Burger
Jul 14, 2007·Current Pharmaceutical Design·G N ChaldakovL Aloe
Oct 6, 2007·International Clinical Psychopharmacology·Mirjam J KnolEibert R Heerdink
Oct 30, 2007·Occupational Medicine·Martin P CosgroveSimon J Griffin
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Sherita Hill GoldenConstantine Lyketsos
Nov 27, 2008·Psychiatric Services : a Journal of the American Psychiatric Association·Tara W StrineKurt Kroenke
Nov 27, 2008·Diabetes Care·Briana MezukSherita Hill Golden
Jun 23, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·R I G HoltUNKNOWN Hertfordshire Cohort Study Group
Aug 4, 2009·Bulletin of the World Health Organization·Sandra G Sosa-RubíRuy López-Ridaura

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Citations

Jun 12, 2016·Journal of the American Medical Directors Association·Nicola VeroneseGiuseppe Sergi
Jun 24, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Lauren B ShomakerJack A Yanovski
Nov 29, 2016·International Journal of Geriatric Psychiatry·Tuğba Akbaş-ŞimşekGünay Can
Mar 24, 2016·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Mariza Miranda Theme FilhaCelia Landmann Szwarcwald
May 18, 2019·American Society of Clinical Oncology Educational Book·Daniel C McFarlandMichelle Riba
Jun 23, 2019·The Diabetes Educator·Lydia O'MearaCorneel Vandelanotte
Sep 19, 2019·Journal of Health Psychology·Thelma Beatriz González-CastroPedro Iván Arias-Vázquez
Jan 7, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica L CastilhoTimothy R Sterling
Sep 1, 2016·Irish Journal of Psychological Medicine·C DolanB Lawlor
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan DuFenghua Fu
Mar 31, 2020·Sleep & Breathing = Schlaf & Atmung·Tomoyuki Kawada
May 10, 2020·Indian Journal of Psychiatry·Arshad HussainWaseem Qureshi
Jan 11, 2019·The Mental Health Clinician·Victoria A SeatonJonell S Hudson
Feb 26, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica L CastilhoTimothy R Sterling
Jun 25, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·E van DuinkerkenR H Griep
Jul 9, 2020·Case Reports in Psychiatry·David C Fipps, Elisabet Rainey
Sep 11, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Marina GarrigaMerete Osler
Feb 27, 2020·Diabetology & Metabolic Syndrome·Jing-Hong LiuChen-Wei Pan
Jul 28, 2019·Annals of General Psychiatry·Norio Yasui-FurukoriNorio Sugawara
Nov 6, 2018·Annals of General Psychiatry·Waleed M Sweileh
Nov 4, 2020·Deutsche medizinische Wochenschrift·Bernhard Kulzer, Lilli Priesterroth
Dec 8, 2020·Clinical Obstetrics and Gynecology·Elisabeth L Stark, Emily S Miller
Sep 25, 2020·Journal of Affective Disorders·Kamila Landucci BonifácioMichael Maes
Nov 13, 2020·Scientific Reports·Inmaculada Guerrero Fernández de AlbaAlexandra Prados-Torres
Nov 18, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Nadine HamiehCedric Lemogne
Dec 22, 2020·Journal of Aging and Health·Seungjong Cho, Tyrone C Hamler
Nov 20, 2020·The Canadian Journal of Cardiology·Darren Lau, Finlay A McAlister

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