Depression and survival outcomes after emergency department cancer pain visits

BMJ Supportive & Palliative Care
Cielito C ReyesKnox H Todd

Abstract

Pain and depression frequently co-occur in patients with cancer. Although pain is a common reason for emergency department (ED) presentation by these patients, depression frequently goes unrecognised during an ED visit. In this study, we assessed the risk for depression in patients with cancer presenting to the ED for uncontrolled pain and assessed the extent to which the risk for depression was associated with survival in this population. Participants were consecutive patients with cancer taking Schedule II opioids (n=209) who presented to the ED of a tertiary cancer centre for uncontrolled pain. Risk for depression was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D), excluding the somatic symptoms. Survival was calculated from date of ED visit to date of death/last follow-up. The CES-D was completed by 197 of 209 participants (94.3%); of these, 81 of 197 (41.1%) had high risk for depression (CES-D ≥10). The mean survival time for the entire sample was 318 days (SD=33), with 84 deaths. Cox proportional hazards regression modeling showed that risk for depression and disease stage (CES-D ≥10: HR=1.75, 95% CI 1.11 to 2.78, p=0.016; disease stage: HR=2.52, 95% CI 1.20 to 5.30, p<0.001) were significant...Continue Reading

References

Jan 1, 1990·International Journal of Psychiatry in Medicine·J M ZichT K Greenfield
Jan 1, 1996·Annual Review of Medicine·G S Norquist, D A Regier
Jan 22, 1997·JAMA : the Journal of the American Medical Association·R M HirschfeldR J Wyatt
Dec 4, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Anita KumarCarlos A Camargo
Feb 24, 2006·Journal of Psychosocial Oncology·Bobbie K ReddickFannie Gaston-Johansson
Oct 4, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine· Institute Of Medicine
Oct 31, 2008·Psychiatric Services : a Journal of the American Psychiatric Association·Margarita AlegríaXiao-Li Meng
Jan 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gregory Luke LarkinDavid P Milzman
Jan 14, 2011·Journal of the National Cancer Institute·Angela B MariottoMartin L Brown
Jun 9, 2011·Journal of the American Geriatrics Society·Ayse AkincigilStephen Crystal
Dec 15, 2012·Critical Reviews in Oncogenesis·Thomas N Seyfried, Leanne C Huysentruyt
Sep 27, 2018·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Yvonne M Buys

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