Depression and the risk of rheumatoid arthritis

Current Opinion in Rheumatology
Isabelle A VallerandCheryl Barnabe

Abstract

Rheumatoid arthritis (RA) is associated with negative changes in mental health. This is generally attributed to symptoms of inflammation and the adverse impact of RA on quality of life and functioning. Until recently, causal pathways in the opposite direction have not been fully appreciated. This review examines the recent literature on the risk of RA associated with depression. Current literature links depression with an increased risk of RA and with a more detrimental disease course. These effects are likely to be partially mediated by negative effects of depression on coping with RA and on factors such as medication adherence, both of which lead to poorer disease outcomes. Growing evidence also suggests that inflammation is central both to depression and RA and may account for some of the complex interplay between these conditions. Awareness of a bidirectional relationship between depression and RA through a biopsychosocial framework may assist clinicians in maintaining an appropriate index of suspicion about the co-occurrence of these conditions. This review also suggests an important need for integration of rheumatologic and mental health services and generates hypotheses for future research towards a better understanding ...Continue Reading

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Citations

Nov 11, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Brittany R LapinIrene L Katzan
Sep 17, 2020·Arthritis Care & Research·Jeffrey A SparksKaren H Costenbader
Apr 2, 2021·Open Access Rheumatology : Research and Reviews·Gianna EspinozaCarlos Rios
Apr 7, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Monika Dmitrzak-WeglarzJoanna Pawlak
Apr 30, 2021·Internet Interventions : the Application of Information Technology in Mental and Behavioural Health·Caitlin BlaneyRenée El-Gabalawy
May 2, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Eric Fakra, Hubert Marotte
May 13, 2021·Open Access Rheumatology : Research and Reviews·Felix BongominMark Kaddumukasa
Aug 17, 2021·Rheumatology and Therapy·Durga P MisraAman Sharma
Apr 30, 2020·Current Rheumatology Reviews·Priya Nijhawan, Tapan Behl

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Methods Mentioned

BETA
pharmacotherapy

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