Depression and thyroid axis function in coronary artery disease: impact of cardiac impairment and gender.

Clinical Cardiology
Robertas BuneviciusSusan S Girdler

Abstract

Increased rates of depression are reported in coronary artery disease (CAD). In heart disease, depression increases disability, reduces quality of life, and increases mortality. The study was undertaken to examine the relationship between depression and thyroid axis function in patients with CAD. In all, 73 patients with CAD, consecutively admitted to a cardiac rehabilitation hospital, were assessed for depression using the Hospital Anxiety and Depression scale (HADS). Blood was drawn for assessment of thyroid axis hormones and the N-amino terminal fragment of the pro-B-type natriuretic peptide (NT-pro BNP). The patients with CAD with depressive symptoms had a higher prevalence of cardiac failure (p = 0.04), higher NT-pro BNP concentrations (p = 0.02), and lower free triiodothyronine (T3) concentrations (p = 0.04) than patients with CAD but without depressive symptoms. They also showed a strong trend (p = 0.058) toward a higher incidence of the low T3 syndrome. Higher NT-pro BNP concentrations were related to lower total T3 concentrations (r = -0.294, p = 0.011) and to higher reverse T3 concentrations (r = 0.353, p = 0.002). In men, higher scores of depression were related to lower total T3 concentration (r = -0.289, p = 0.034)...Continue Reading

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Citations

Jan 1, 2012·Health Psychology Review·Jonathan A ShafferKarina W Davidson
Nov 10, 2011·The Journal of Cardiovascular Nursing·Margarita StaniuteRobertas Bunevicius
Sep 14, 2012·PloS One·Insa FeinkohlUNKNOWN Edinburgh Type 2 Diabetes Study-ET2DS Investigators
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Dec 28, 2011·Journal of Psychosomatic Research·Adomas BuneviciusRobertas Bunevicius
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Nov 23, 2006·Depression and Anxiety·Adomas BuneviciusRobertas Bunevicius
Oct 2, 2012·Psychosomatic Medicine·Adomas BuneviciusRobertas Bunevicius
Sep 16, 2014·Expert Review of Cardiovascular Therapy·Laura SabatinoAlessandro Pingitore
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Feb 13, 2015·Expert Review of Neurotherapeutics·Adomas BuneviciusRobertas Bunevicius
Feb 9, 2017·International Journal of Geriatric Psychiatry·Jiyun ZhaoJincai He
Aug 1, 2020·Frontiers in Physiology·Kaihao WangAnthony Martin Gerdes

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