Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence

Annals of Medicine
Setor Kwadzo KunutsorKamlesh Khunti

Abstract

Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. Eligible studies were identified in a literature search of MEDLINE, Embase, Web of Science and reference list of relevant studies up to April 2018. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were aggregated using random effects models. Eight observational studies with data on 960 113 nonoverlapping participants and 9027 VTE cases were included. The pooled RR (95% CI) for VTE comparing antidepressant use with no antidepressant use was 1.27 (1.06-1.51). Tricyclic antidepressants, selective serotonin reuptake inhibitors and other antidepressants were each associated with an increased VTE risk; 1.16 (1.06-1.27), 1.12 (1.02-1.23), and 1.59 (1.21-2.09), respectively. In pooled analysis of three studies that compared patients with depression versus individuals without depression, the RR for VTE was 1.31 (1.13-1.53). Pooled observational evidence suggests that depression and use of antidepressants are each associated with an increase...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 1, 1996·The American Journal of Psychiatry·D L MusselmanC B Nemeroff
Apr 21, 1999·Lancet·F R Rosendaal
Oct 16, 1999·Statistics in Medicine·S G Thompson, S J Sharp
Feb 14, 2002·British Journal of Haematology·Benien E van AkenFrits R Rosendaal
May 3, 2002·The American Journal of Psychiatry·Danilo ArnoneGwyn Davies
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 7, 2004·Pharmacoepidemiology and Drug Safety·Lianne ParkinCharlotte Paul
Apr 23, 2004·Journal of Thrombosis and Haemostasis : JTH·P H Reitsma, F R Rosendaal
Apr 17, 2007·Seminars in Hematology·Mary Cushman
Oct 17, 2007·Thrombosis and Haemostasis·Alexander T CohenUNKNOWN VTE Impact Assessment Group in Europe (VITAE)
Nov 30, 2007·Journal of Thrombosis and Haemostasis : JTH·A RosengrenH Eriksson
Dec 7, 2007·Annals of Internal Medicine·James D DouketisPaolo Prandoni
Jan 30, 2008·Pharmacotherapy·Susan S Jick, Lin Li
Apr 22, 2009·Journal of the Royal Statistical Society. Series A, (Statistics in Society)·Julian P T HigginsDavid J Spiegelhalter
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Aug 5, 2009·Archives of General Psychiatry·Mark Olfson, Steven C Marcus
Feb 12, 2011·BMJ : British Medical Journal·Richard D RileyJonathan J Deeks
Feb 10, 2012·Thrombosis and Haemostasis·Kristin F EngaJohn-Bjarne Hansen
Mar 24, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Stephen Ilyas, Joanna Moncrieff
Jan 2, 2013·Journal of Clinical Psychopharmacology·Chi-Shin WuHui-Ju Tsai
Oct 12, 2013·Seminars in Thrombosis and Hemostasis·Anthony W AustinRoland von Kanel
May 20, 2015·Psychosomatic Medicine·Cynthia Wei-Sheng LeeChia-Hung Kao
Jun 17, 2015·Nature Reviews. Cardiology·John A Heit
Sep 12, 2015·ClinicoEconomics and Outcomes Research : CEOR·Maria M FernandezWinghan Jacqueline Kwong
May 19, 2017·Journal of the American Heart Association·Lianne ParkinUNKNOWN Million Women Study Collaborators
May 19, 2017·Journal of the American Heart Association·Brian R Branchford

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Citations

Sep 7, 2018·British Journal of Hospital Medicine·Joanna Garstang, Nick Townsend
Jan 14, 2020·Psychiatry and Clinical Neurosciences·Takuto IshidaHiroyuki Uchida
Mar 13, 2020·Neuropsychiatric Disease and Treatment·Masahiro TakeshimaKazuo Mishima
Dec 22, 2020·Focus : Journal of Life Long Learning in Psychiatry·Giovanni OstuzziCorrado Barbui

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