Abstract
The current study was designed to investigate the changes that occur in depression, anxiety, obsessive-compulsive symptoms and health-related quality of life during methylphenidate (MPH) treatment in children with attention-deficit hyperactivity disorder (ADHD). Forty-five treatment naive children with ADHD, aged 8-14, were assessed based on self, parent and teacher reports at the baseline and at the end of the first and third month of MPH treatment regarding changes in inattention, hyperactivity, impulsivity, depression, anxiety and obsessive-compulsive symptoms. Changes in the quality of life were also noted. Repeated measures of analysis of variance (ANOVA) tests with Bonferroni corrections were conducted in order to evaluate the data. Symptoms of inattention, hyperactivity and impulsivity were significantly reduced (p < 0.017) following a three-month MPH treatment. There were significant decreases in depression (p = 0.004), trait anxiety (p = 0.000) and checking compulsion symptom scores (p = 0.001). Moreover, parents reported significant improvements in psychosocial (p = 0.001) and total scores (p = 0.009) of quality of life, despite no change in physical health scores (p > 0.05). Children's ratings of quality of life meas...Continue Reading
References
Jan 1, 1977·Behaviour Research and Therapy·R J Hodgson, S Rachman
Mar 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·S R Pliszka
Aug 1, 1991·Journal of Clinical Psychopharmacology·R T JoffeA J Levitt
Jul 1, 1990·Psychiatry Research·B G BorcherdingJ Amass
Dec 1, 1987·Journal of Clinical Psychopharmacology·R T Joffe, R P Swinson
Jul 1, 1972·Clinical Pharmacology and Therapeutics·K RickelsH S Wentz
May 1, 1970·Journal of the American Podiatry Association·S R Kaner
Jan 1, 1995·International Journal of Psychiatry in Medicine·F FernandezP Ruiz
Jul 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·R TannockR Schachar
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·G J DuPaulM B McMurray
Aug 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·D P Cantwell
Jul 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·J KaufmanN Ryan
Feb 25, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·S Kouris
Aug 13, 1998·Journal of Abnormal Child Psychology·C K ConnersJ N Epstein
Aug 13, 1998·Journal of Abnormal Child Psychology·C K ConnersJ N Epstein
Feb 19, 1999·Medical Care·J W VarniC A Rode
Apr 13, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·I R DiamondR J Schachar
Feb 9, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Laurence L GreenhillUNKNOWN American Academy of Child and Adolescent Psychiatry
Aug 24, 2004·European Child & Adolescent Psychiatry·Christopher GillbergLena Niklasson
Nov 3, 2004·Pediatrics·Anne F KlassenStuart Fine
Jan 11, 2005·Human Psychopharmacology·Hoon LeeJin-Sang Yoon
Jun 30, 2005·Journal of Psychiatric Practice·Margaret WeissGabrielle Weiss
Jul 19, 2005·Lancet·Joseph Biederman, Stephen V Faraone
Jun 21, 2006·Child: Care, Health and Development·A F KlassenS Fine
Feb 8, 2007·The Journal of Clinical Psychiatry·Frederick W ReimherrBarrie K Marchant
May 8, 2007·European Child & Adolescent Psychiatry·L Hakkaart-van RoijenJ K Buitelaar
Aug 11, 2007·Journal of Child Neurology·Helly GoezNathanel Zelnik
Nov 14, 2007·The Australian and New Zealand Journal of Psychiatry·Pinchen YangMei-Chyn Chao
Mar 21, 2008·Developmental Medicine and Child Neurology·Boudien C T Flapper, Marina M Schoemaker
Jan 24, 2009·European Archives of Psychiatry and Clinical Neuroscience·Michael RöslerWolfgang Retz
Citations
Sep 9, 2011·European Child & Adolescent Psychiatry·Aribert RothenbergerManfred Döpfner
May 2, 2014·Annales pharmaceutiques françaises·H JavelotB Kabuth
Oct 24, 2012·Journal of Psychiatric Research·Antonio Molina-CarballoAntonio Muñoz-Hoyos
Nov 3, 2015·Behavioural Brain Research·Ashley J PorterJared W Young
Jan 7, 2015·Genes, Brain, and Behavior·A J PorterS C Stanford
Oct 29, 2014·European Child & Adolescent Psychiatry·Arunima RoyAlbertine J Oldehinkel
Oct 22, 2013·International Journal of Pediatric Otorhinolaryngology·Kemal ÖzcanKübra Durukan
Mar 10, 2017·Expert Opinion on Drug Safety·Annabeth P GroenmanPieter J Hoekstra
Feb 21, 2013·Journal of Attention Disorders·Anthony RostainStephen V Faraone
May 15, 2016·Journal of Attention Disorders·Helen GallowayClare Yuill
Feb 8, 2019·PloS One·Fang-Ju TsaiSusan Shur-Fen Gau
Feb 10, 2019·Molecular Brain·Rongyi ZhouYuchen Song
Mar 29, 2019·Clinical Neuropharmacology·Rukiye Çolak Sivri, Burçin Çolak
Jun 28, 2011·CNS Drugs·Anat AbudyJoseph Zohar
Dec 17, 2019·Journal of Child and Adolescent Psychopharmacology·Tanya E FroehlichJeffery N Epstein
Apr 17, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sara Loureiro-VieiraJoão Paulo Capela
May 1, 2018·Journal of Attention Disorders·Seda Erbilgin Gün, Ayse Kilincaslan
Mar 7, 2012·Arquivos de neuro-psiquiatria·Elizabeth Zambrano-SánchezAdrián Poblano
Jul 28, 2016·Journal of Psychopharmacology·Katharine PillidgeS Clare Stanford
Aug 30, 2017·Molecular Medicine Reports·Rong-Yi ZhouXin-Min Han
Oct 28, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Carlos CaronaHelena Moreira
Apr 22, 2016·Journal of Psychopharmacology·Katharine PillidgeS Clare Stanford
Dec 23, 2016·Attention Deficit and Hyperactivity Disorders·Helen Galloway, Emily Newman
Oct 22, 2020·International Clinical Psychopharmacology·Pavel Golubchik, Abraham Weizman
Dec 29, 2020·Epilepsy & Behavior : E&B·Beth A Leeman-MarkowskiKimford J Meador
Jun 1, 2021·Frontiers in Psychiatry·Ezgi Dogan-Sander, Maria Strauß