Depression is an early disease manifestation in lupus-prone MRL/lpr mice.

Journal of Neuroimmunology
Hua-Xin GaoChaim Putterman

Abstract

Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.

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Citations

Jan 15, 2011·Clinical Reviews in Allergy & Immunology·Michal BenklerYehuda Shoenfeld
Apr 13, 2013·Journal of Autoimmunity·Jing WenChaim Putterman
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Maria Gulinello, Chaim Putterman
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