Depression is Associated with Tau and Not Amyloid Positron Emission Tomography in Cognitively Normal Adults.

Journal of Alzheimer's Disease : JAD
Ganesh M BabulalBeau M Ances

Abstract

Depression is also common with older age. Alzheimer's disease (AD) studies suggest that both cerebrospinal fluid and positron emission tomography (PET) amyloid biomarkers are associated with more depressive symptoms in cognitively normal older adults. The recent availability of tau radiotracers offers the ability to examine in vivo tauopathy. It is unclear if the tau biomarker is associated with depression diagnosis. We examined if tau and amyloid imaging were associated with a depression diagnosis among cognitively normal adults (Clinical Dementia Rating = 0) and whether antidepressants modified this relationship. Among 301 participants, logistic regression models evaluated whether in vivo PET tau was associated with depression, while another model tested the interaction between PET tau and antidepressant use. A second set of models substituted PET amyloid for PET tau. A diagnosis of depression (yes/no) was made during an annual clinical assessment by a clinician. Antidepressant use (yes/no) was determined by comparing medications the participants used to a list of 30 commonly used antidepressants. All models adjusted for age, sex, education, race, and apolipoprotein ɛ4. Similar models explored the association between the biom...Continue Reading

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Citations

Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Bethany HulmeChris Murgatroyd
Jan 28, 2021·Translational Psychiatry·Maurits JohanssonOskar Hansson
Feb 17, 2021·Neurobiology of Aging·Gwenn S SmithClifford I Workman
Apr 6, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Cécile TissotSerge Gauthier
May 25, 2021·Journal of Alzheimer's Disease : JAD·Mitzi M GonzalesSudha Seshadri

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Methods Mentioned

BETA
chip

Software Mentioned

FreeSurfer
SPSS

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