Depression is the strongest predictor of long-term outcome in patients with chronic nonischemic heart failure

Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery
Bozena Szyguła-JurkiewiczLech Poloński

Abstract

Despite advances in medicine, chronic heart failure (CHF) still remains a significant clinical problem associated with poor outcome. To determine risk factors for major adverse cardiac events (MACE) in three-year follow-up in patients with CHF of nonischemic etiology. The prospective study included consecutive hospitalized patients with stable CHF (LVEDD > 57 mm; LVEF < 40%) and symptom duration > 6 months. Study exclusion criteria were: serious neurological and/or psychiatric diseases, stenoses in epicardial coronary arteries in coronarography, active myocarditis confirmed by myocardial biopsy, diseases of the respiratory system with pulmonary hypertension, presence of heart defects, neoplastic or connective tissue disease, documented infectious diseases at least three months before inclusion in the study, diabetes, liver cirrhosis, chronic kidney disease (eGFR < 30 ml/min/1.73 m(2)), alcoholism, planned heart transplantation. Depression severity was assessed with the Beck and the Hamilton Scales. Depression was diagnosed based on the ICD-10 criteria. Clinical follow-up began on admission and lasted three years. The analysis encompassed 199 patients aged 49 (41-54), who met the inclusion/exclusion criteria. Depression was diag...Continue Reading

Methods Mentioned

BETA
biopsy
pharmacotherapy

Software Mentioned

Statistica
R
MS Office Excel

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