Depression of cardiac function after deep hypothermic circulatory arrest in deeply anesthetized neonatal lambs

The Journal of Thoracic and Cardiovascular Surgery
H VelvisJ Vinten-Johansen

Abstract

Cardiac dysfunction is common after neonatal cardiac operations. Previous in vivo studies in neonatal animal models however, have failed to demonstrate decreased left ventricular function after ischemia and reperfusion. Cardiac dysfunction may have been masked in these studies by increased endogenous catecholamine levels associated with the use of light halothane anesthesia. Currently, neonatal cardiac operations are often performed with deep opiate anesthesia, which suppresses catecholamine surges and may affect functional recovery. We therefore examined the recovery of left ventricular function after ischemia and reperfusion in neonatal lambs anesthetized with high-dose fentanyl citrate (450 micrograms/kg administered intravenously). Seven intact neonatal lambs with open-chest preparation were instrumented with left atrial and left ventricular pressure transducers, left ventricular dimension crystals, and a flow transducer. The lambs were cooled (< 18 degrees C) on cardiopulmonary bypass (22 +/- 6 minutes), exposed to deep hypothermic circulatory arrest (46 +/- 1 minutes), and rewarmed on cardiopulmonary bypass (30 +/- 10 minutes). Catecholamine levels and indexes of left ventricular function were determined before (baseline)...Continue Reading

References

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Citations

Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Ingeborg FriehsPedro J del Nido
Oct 22, 2011·The Journal of Thoracic and Cardiovascular Surgery·Alessio RungatscherGiuseppe Faggian
Oct 22, 2013·Critical Care : the Official Journal of the Critical Care Forum·Alessio RungatscherGiuseppe Faggian
Jan 6, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Guillaume DebatyRaphaël Briot

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