Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit

Journal of Applied Physiology
Donatella MutoloTito Pantaleo

Abstract

We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components of the cough motor pattern. These findings led us to suggest that the cVRG region, and possibly other neural substrates involved in cough regulation, may be sites of action of antitussive drugs. To address this issue, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation following microinjections (30-50 nl) of some antitussive drugs into the cVRG of pentobarbital-anesthetized, spontaneously breathing rabbits. [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) and baclofen at the lower concentrations (0.5 mM and 0.1 mM, respectively) decreased cough number, peak abdominal activity, and peak tracheal pressure and increased cough-related total cycle duration (Tt). At the higher concentrations (5 mM and 1 mM, respectively), both drugs abolished the cough reflex. DAMGO and baclofen also affected baseline respiratory activity. Both drugs reduced peak abdominal activity, while only DAMGO increased Tt, owing to increases...Continue Reading

References

Oct 2, 1991·European Journal of Pharmacology·J KameiY Kasuya
Mar 1, 1989·The Journal of Comparative Neurology·J C SmithJ L Feldman
Mar 1, 1989·The American Journal of Physiology·A C Bonham, I Jeske
Jun 8, 1989·The Journal of Comparative Neurology·G Holstege
Dec 1, 1995·Journal of Neurophysiology·S P ZhangP J Davis
Oct 1, 1996·Pulmonary Pharmacology·C Advenier, X Emonds-Alt
Mar 5, 1998·The American Journal of Physiology·E Seifert, T Trippenbach
May 12, 1998·The American Journal of Physiology·F BongianniT Pantaleo
Oct 17, 1998·Progress in Neurobiology·S Iscoe
Mar 6, 1999·Journal of Applied Physiology·D C BolserR W Chapman
Jan 19, 2000·Experimental Brain Research·C GestreauA L Bianchi
Jul 7, 2000·Pharmacology & Therapeutics·A HajiM Okazaki
Mar 10, 2001·Respiration Physiology·G Sant'Ambrogio, J Widdicombe
May 31, 2002·Pharmacological Reviews·Cinzia SeveriniVittorio Erspamer
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donatella MutoloTito Pantaleo
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Donald C Bolser, Paul W Davenport
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Tito PantaleoDonatella Mutolo
Aug 24, 2002·Pflügers Archiv : European journal of physiology·Fulvia BongianniTito Pantaleo
Jul 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley
Jan 1, 1954·The Journal of Physiology·J G WIDDICOMBE
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Jesse P JoadAnn C Bonham
Feb 6, 2004·European Journal of Pharmacology·Richard W ChapmanJohn A Hey
Jul 23, 2004·Physiological Reviews·Bernhard BettlerMartin Gassmann
Nov 27, 2004·Pulmonary Pharmacology & Therapeutics·R ShannonB G Lindsey
May 10, 2005·Respiratory Physiology & Neurobiology·John Widdicombe, Vijay Singh
Jul 30, 2005·The Journal of Physiology·Stuart B MazzoneBrendan J Canning
Mar 24, 2006·Respiratory Physiology & Neurobiology·Ann C BonhamJesse P Joad
Apr 6, 2006·Respiratory Physiology & Neurobiology·Jan HanacekJohn Widdicombe
May 26, 2006·Respiratory Physiology & Neurobiology·Donald C BolserPaul W Davenport
Jul 4, 2006·The European Respiratory Journal·J Widdicombe, G Fontana
Dec 27, 2006·Pulmonary Pharmacology & Therapeutics·Peter J Barnes
Feb 13, 2007·Pulmonary Pharmacology & Therapeutics·Giovanni A Fontana, John Widdicombe

❮ Previous
Next ❯

Citations

Jan 9, 2014·Physiological Reports·Elenia CinelliDonatella Mutolo
Jun 15, 2011·Current Opinion in Pharmacology·Stuart B MazzoneMichael J Farrell
Apr 16, 2016·Pulmonary Pharmacology & Therapeutics·Donatella MutoloFulvia Bongianni
Mar 21, 2015·Current Opinion in Pharmacology·Kian Fan Chung
Aug 30, 2012·Respiratory Physiology & Neurobiology·Ivan PoliacekJan Jakus
May 28, 2017·Respiratory Physiology & Neurobiology·Donatella Mutolo
Feb 4, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donatella MutoloTito Pantaleo
Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page
Oct 3, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donatella MutoloTito Pantaleo
Jul 13, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elenia CinelliDonatella Mutolo
Sep 29, 2020·British Journal of Clinical Pharmacology·Christian StrausThomas Similowski
Nov 19, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hai-Feng ZongLin-Lin Bao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.