Depression of cyclooxygenase-2 induction in aortas of rats with type 1 and type 2 diabetes mellitus

European Journal of Pharmacology
Yuji Takahashi, Ichiro Wakabayashi

Abstract

The purpose of this study was to determine whether cyclooxygenase expression in arteries is affected by diabetes. Streptozotocin-injected rats and Goto-Kakizaki rats were used as animal models for type 1 and type 2 diabetes, respectively. Cyclooxygenase-2 expression was induced by lipopolysaccharide. Lipopolysaccharide-induced cyclooxygenase-2 expression was significantly lower in aortas isolated from streptozotocin-injected rats and Goto-Kakizaki rats than in aortas of control rats, while expression level of cyclooxygenase-1 was not affected by lipopolysaccharide and was not different in aortas of the three groups of rats. The level of 6-keto-prostaglandin F(1alpha) that accumulated in the presence of lipopolysaccharide as well as the basal accumulation level in the absence of lipopolysaccharide was significantly lower in aortas of streptozotocin-injected rats and Goto-Kakizaki rats than in aortas of control rats. The net increase in 6-keto-prostaglandin F(1alpha) level in response to stimulation with lipopolysaccharide, which was calculated by subtracting the basal accumulation level from the total accumulation level, was also significantly lower in aortas of streptozotocin-injected rats and Goto-Kakizaki rats than in aortas ...Continue Reading

References

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Dec 16, 2006·The American Journal of Cardiology·Peter Libby

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Citations

Dec 9, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Aaron P KelloggRodica Pop-Busui
Aug 25, 2010·Cytokine·Sukriye YesilotEkrem Cicek
Apr 29, 2010·Journal of Pharmacological Sciences·Tomoyuki Nakano, Ichiro Wakabayashi
Jul 4, 2018·Oxidative Medicine and Cellular Longevity·Andrzej FedorowiczStefan Chlopicki

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