Depression of guanosine diphosphate-mannose pyrophosphorylase by mutations in two different regulator genes involved in capsular polysaccharide synthesis in Escherichia coli K-12.

Journal of Bacteriology
M M Lieberman, A Markovitz

Abstract

Mutations in a regulator gene (capR) that causes increased synthesis of capsular polysaccharide and derepressed synthesis of several enzymes involved in polysaccharide synthesis also derepress synthesis of guanosine diphosphate (GDP)-mannose pyrophosphorylase. In addition, a second mucoid mutation (capS, which maps separately from capR) also results in the derepression of GDP-mannose pyrophosphorylase. New conditions for assaying GDP-mannose hydrolyase and GDP-l-fucose synthetase permitted us to show that these enzymes are also derepressed in the capS mucoid strain. Although phosphomannose isomerase and uridine diphosphate-galactose-4-epimerase are derepressed in capR mucoid strains, they are not derepressed in capS mucoid strains. A nonmucoid mutant of a strain containing the capR9 (mucoid) allele was deficient in GDP-mannose pyrophosphorylase.

References

Dec 1, 1967·Bacteriological Reviews·A L Taylor, C D Trotter
Jan 1, 1968·Molecular & General Genetics : MGG·J Donch, J Greenberg
Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·A Markovitz, N Rosenbaum
Feb 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·A MARKOVITZ
May 1, 1964·Journal of General Microbiology·N J PALLERONI, R Y STANIER
Aug 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·R V SAPELLI, W F GOEBEL
Dec 1, 1959·Proceedings of the National Academy of Sciences of the United States of America·H M KalckarE Jordan

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Citations

Jun 1, 1973·European Journal of Biochemistry·M Norval, I W Sutherland
Jan 1, 1980·Molecular & General Genetics : MGG·B Diderichsen
Oct 1, 2014·The ISME Journal·Samuel J Tazzyman, Alex R Hall
Nov 27, 2015·Molecular Biology and Evolution·Sébastien WielgossAlex R Hall
Jun 1, 1972·Journal of Bacteriology·S S Hua, A Markovitz
Mar 1, 1975·Journal of Bacteriology·R E Hancock, P Reeves
Sep 1, 1977·Bacteriological Reviews·I OrskovK Jann
Jan 12, 1973·Biochimica Et Biophysica Acta·J G SchillerD S Feingold
Dec 1, 1973·Journal of Bacteriology·B Shineberg, D Zipser
Nov 1, 1975·Journal of Bacteriology·A J Klar, H O Halvorson

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