PMID: 6972935Jun 1, 1981Paper

Depression of hepatic mixed-function oxidase activity by B. pertussis in splenectomized and athymic nude mice

Immunopharmacology
J F WilliamsA Szentivanyi

Abstract

Administration of Bordetella pertussis (B. pertussis), Corynebacterium parvum (C. parvum), and several other immunoactive substances is known to cause a marked decrease in the activity of the hepatic microsomal mixed-function oxidase system. The effect of C parvum has been reported to involve the reticuloendothelial system. In the present study, the effect of B. pertussis administration to decrease hepatic microsomal drug metabolism was studied in unoperated, sham-operated, and splenectomized mice as well as in athymic nude (nu/nu) mice and their phenotypically heterozygous (+/nu) littermates. Administration of B. pertussis to the splenectomized, sham-operated, and unoperated mice resulted in a decrease in the activity of the microsomal enzyme system that was approximately the same for each of the three groups of animals. Administration of B. pertussis to nu/nu mice and the +/nu mice also decreased the microsomal enzyme activity measured 24 hr after injection. However, at 7 days after B. pertussis administration, the hepatic drug-metabolizing activity of the nu/nu mice was not significantly different from control values, whereas the activity of the +/nu mice was still significantly depressed. The failure of splenectomy to preve...Continue Reading

References

Nov 22, 1976·Biochemical and Biophysical Research Communications·K W Renton, G J Mannering
Feb 1, 1976·Biochemical Pharmacology·F GorodischerS J Yaffe
Jun 1, 1977·European Journal of Pharmacology·J F Williams, A Szentivanyi
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Citations

Sep 1, 1994·International Journal of Immunopharmacology·S G Armstrong, K W Renton
Nov 1, 1989·Journal of Gastroenterology and Hepatology·I A al-MoflehA S al-Tuwaijri
Feb 28, 2019·The Journal of Pharmacy and Pharmacology·Amarjot Kaur GrewalThakur Gurjeet Singh
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fang HuaChuanfu Li

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