Depression of mechanical performance by active shortening during twitch and tetanus of vertebrate muscle fibres

Acta Physiologica Scandinavica
K A Edman

Abstract

Shortening during activity of frog single muscle fibres caused a graded depression of the contractile force that persisted for 800-900 ms during a partially fused or completely fused tetanus. The depression of force was not associated with a change of the shortening velocity at zero load. Passive shortening performed just before stimulation had no effect on the subsequent course of contraction. The decrease in isometric force produced by shortening was not significantly affected by a stretch applied immediately before or after the shortening was not significantly affected by a stretch applied immediately before or after the shortening phase. For a given amount of shortening the depressant effect during a fused tetanus was 8-28% of that produced during a twitch. The effect was substantially reduced, both during twitch and tetanus, in the presence of 0.5 mM caffeine. The length dependence of the movement effect was studied between 1.7 and 2.9 micrometer sarcomere spacing. Maximum depression of force (in per cent of the control at each length) was obtained at 2.1-2.2 micrometer sarcomere length, the effect being steadily reduced at shorter and more extended lengths. The Q10 of the depressant effect was 0.95 +/- 0.16 (S.D.). The fe...Continue Reading

References

Jul 1, 1978·Physiological Reviews·N A Curtin, R C Woledge
Apr 1, 1978·The Journal of Physiology·J R BlinksS R Taylor
Jan 1, 1978·Annual Review of Physiology·E Homsher, C J Kean
Jan 1, 1976·Annual Review of Physiology·S Ebashi
Mar 1, 1974·The Journal of Physiology·B H Bressler, N F Clinch
Aug 1, 1972·The Journal of General Physiology·K L Briden, N R Alpert
Sep 1, 1972·The Journal of General Physiology·E Bozler
Sep 1, 1973·The Journal of Physiology·V A Dickinson, R C Woledge
Jan 1, 1973·Physiological Reviews·B C Abbott, J V Howarth
Oct 22, 1971·Nature·A F Huxley, R M Simmons
Oct 1, 1969·The Journal of Physiology·G C Joyce, P M Rack
May 1, 1966·The Journal of Physiology·A M GordonF J Julian
Jun 1, 1966·The Journal of Physiology·M M Civan, R J Podolsky
Jun 1, 1966·The Journal of Physiology·A J Brady
Mar 17, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL
Jun 1, 1960·The Journal of Physiology·B R JEWELL, D R WILKIE

❮ Previous
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Citations

Jan 1, 1987·European Journal of Applied Physiology and Occupational Physiology·D GravelC L Richards
Mar 1, 1983·Pflügers Archiv : European journal of physiology·P J Kil, P Schiereck
Sep 1, 1996·Pflügers Archiv : European journal of physiology·R S JamesJ D Altringham
Jan 4, 2006·Protoplasma·R Jarosch
Jan 1, 1982·Pharmacology & Therapeutics·B Wohlfart, M I Noble
Nov 19, 2002·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Kenneth Meijer
Oct 1, 1982·Acta Physiologica Scandinavica·M C Ekelund, K A Edman
Apr 1, 1984·Acta Physiologica Scandinavica·J EkströmM C Ekelund
May 1, 1985·Acta Physiologica Scandinavica·A R Khan, B Bengtsson
Dec 1, 1983·Archives internationales de physiologie et de biochimie·F A Van KaamP Schiereck
Apr 11, 2009·The Journal of Physiology·Monica A DaleyAndrew A Biewener
Jan 1, 1987·Archives of Oral Biology·F C AnapolJ H Fuller
Oct 1, 1996·Archives of Physical Medicine and Rehabilitation·S NadeauM Goyette
Dec 24, 2015·Medicine and Science in Sports and Exercise·Maarten Frank BobbertArthur J Van Soest
Jun 22, 2002·Journal of Theoretical Biology·Jachen DenothGaudenz Danuser
Jan 1, 1987·Journal of Biomechanics·R D WoittiezW H Rijnsburger
Oct 6, 1998·Journal of Dental Research·G E SlagerJ D van Willigen
Nov 2, 2016·The Journal of Experimental Biology·Dean L MayfieldGlen A Lichtwark
Aug 1, 1997·Journal of Applied Physiology·R S JamesD F Goldspink
Oct 1, 1991·Journal of Muscle Research and Cell Motility·D A Smith
Oct 1, 1985·Journal of Muscle Research and Cell Motility·J D Altringham, R Bottinelli
Apr 4, 2000·Physiological Reviews·A M GordonM Regnier
Sep 18, 1997·Journal of Applied Physiology·X ShenS J Gunst
Dec 1, 1992·Journal of Muscle Research and Cell Motility·K Burton
Sep 1, 2012·Biophysics Reviews·Carlos BazanPaul Paolini
Jan 13, 2004·Journal of Applied Physiology·Dilson E Rassier, Walter Herzog

❮ Previous
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