Depression one year after hemorrhagic stroke is associated with late worsening of outcomes

NeuroRehabilitation
Sara Stern-NezerMarion S Buckwalter

Abstract

Poststroke depression is the most common psychiatric sequelae of stroke, and it's independently associated with increased morbidity and mortality. Few studies have examined depression after intracranial hemorrhage (ICH). To investigate the relationship between depression, ICH and outcomes. A substudy of the prospective Diagnostic Accuracy of MRI in Spontaneous Intracerebral Hemorrhage (DASH) study, we included 89 subjects assessed for depression 1 year after hemorrhage. A Hamilton Depression Rating Scale score >10 defined depression. Univariate, multivariable, and trend analyses evaluated relationships between depression, clinical, radiographic, and inflammatory factors and modified Rankin score (mRS) at 90 days and one year. Prevalence of depression at one year was 15%. Depression was not associated with hematoma volumes, presence of IVH or admission NIHSS, nor with demographic factors. Despite this, depressed patients had worse 1-year outcomes (p = 0.004) and were less likely to improve between 3 and 12 months, and more likely to worsen (p = 0.042). This is the first study to investigate depression one year after ICH. Post-ICH depression was common and associated with late worsening of disability unrelated to initial hemorrha...Continue Reading

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Citations

Mar 25, 2019·Brain and Behavior·Hanne SallinenDaniel Strbian
Aug 1, 2018·Frontiers in Neurology·Oleg A Levada, Alexandra S Troyan
Jan 9, 2019·Frontiers in Psychiatry·Yinan WuAnwen Shao
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Dec 31, 2020·Stroke and Vascular Neurology·Qian BaiMengzhou Xue
Apr 16, 2021·International Journal of General Medicine·Cuihua ZouXuebin Li
Oct 1, 2021·Stroke; a Journal of Cerebral Circulation·Juan Pablo CastelloAlessandro Biffi

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