Depression predicts cognitive disorders in older primary care patients

The Journal of Clinical Psychiatry
Lisa L BoyleJeffrey M Lyness

Abstract

To investigate whether depression is independently associated with increased risk of incident dementia or cognitive disorder not otherwise specified (NOS) in an older primary care population. This was a prospective 3-year cohort study of 470 patients aged >or= 65 years without baseline cognitive disorders who were recruited from primary care offices. Annual assessments completed from March 2003 through December 2005 included the use of the Structured Clinical Interview for DSM-IV to diagnose major depressive disorder (MDD) and minor depression (MinD) and the Hamilton Depression Rating Scale (HDRS) for depressive symptom severity. The Mini-Mental State Exam, Mattis Dementia Rating Scale-initiation/perseveration subscale, and the Trail Making Tests A and B informed diagnoses of dementia and cognitive disorder NOS. 36 subjects, representing a cumulative incidence of 13%, developed dementia or cognitive disorder NOS over 3 years. Using Cox proportional hazard survival models to calculate the risk ratio of depression for development of cognitive disorders, MDD and MinD (HR = 3.68; 95% CI, 2.1-6.42 and HR = 1.84; 95% CI, 1.05-3.21, respectively) and HDRS scores (HR = 1.07; 95% CI, 1.02-1.12) predicted new onset dementia or cognitive ...Continue Reading

Citations

Jan 25, 2012·Zeitschrift für Gerontologie und Geriatrie·G TheileU Junius-Walker
May 3, 2014·Clinical Interventions in Aging·Anokha PadubidriMukaila A Raji
Dec 5, 2012·The Journal of Nutrition, Health & Aging·A CherubiniM Trabucchi
Aug 23, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Brooke SchneiderHelen Lavretsky
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Jul 12, 2011·International Journal of Geriatric Psychiatry·R Scott MackinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 15, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sabrina C da CostaFlavio Kapczinski
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Jun 20, 2017·Brain Research Bulletin·Ming-Di JiangYu-Feng Wang
Oct 10, 2019·The Australian and New Zealand Journal of Psychiatry·Dae Jong OhKi Woong Kim
Jan 1, 2021·Journal of Geriatric Psychiatry and Neurology·Deborah M OyeyemiUNKNOWN MADCO-PC Study Team Investigators

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