Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
A FattoriILDE Study Group

Abstract

Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL. Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information). A psychiatrist completed a standardized data collection form encompassing a depression severity scale (MADRS) and clinical information. There was a strong graded association between the severity of depressive symptoms and both the physical (ω 2 = 0.13; p < 0.01) and mental (ω 2 = 0.34; p < 0.01) SF-12 domains. Additionally, we observed a strong association between concentration difficulties and all HRQOL outcomes independent of other symptoms of depression and robust to adjustment for possible confounders. Our data corroborate previous findings suggesting that cognitive impairment is a feature of unipolar depressive disorders partially inde...Continue Reading

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Citations

Sep 8, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Mark ZimmermanKasey Stanton
Dec 30, 2018·Journal of Affective Disorders·R García-VelázquezT H Rosenström
Aug 20, 2018·Journal of Affective Disorders·John G KeilpJ John Mann

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