Depression symptomatology and neurobiology

The Journal of Clinical Psychiatry
Alan J Gelenberg

Abstract

The DSM-IV-TR distinguishes major depressive disorder (MDD) from normal sadness and grief by requiring a certain duration and number of symptoms that cause impairment and dysfunction. Depression is considered a heterogeneous condition in which different biologic abnormalities may be responsible for problems with sleeping, eating, energy, and emotional reactions. Neuroimaging, pharmacology, and genomics are among the sources of information that have contributed to theories about the pathophysiology of MDD and may lead to truly personalized medicine in the future.

Citations

Feb 19, 2013·Neuroscience and Biobehavioral Reviews·Eva Morava, Tamás Kozicz
Nov 8, 2015·Psychoneuroendocrinology·Licínia GanançaM Elizabeth Sublette
Nov 6, 2013·Progress in Neurobiology·Alessio BarsagliniAndrea Mechelli
Feb 1, 2013·The International Journal of Neuropsychopharmacology·Elliott Richelson
Jul 16, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elizabeth A FucichDavid A Morilak
May 26, 2017·International Review of Psychiatry·Vanderson Esperidião-AntonioRodrigo Siqueira-Batista

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