Depression trajectories and the association with metabolic adversities among the middle-aged adults

Journal of Affective Disorders
Eun Young KimYong Min Ahn

Abstract

Despite both depression and metabolic disturbances confer substantial burden of disease, natural course of depressive symptoms and the relationship with metabolic adversities have not examined. We explore associations between trajectories of depressive symptoms and metabolic disturbance, lifestyle factors and comorbidities. This retrospective cohort study included 13,745 subjects (8113 men and 5632 women) 40-59 years of age who underwent health examinations at the Seoul National University Hospital Healthcare System, Gangnam Center, in Korea. The median follow-up duration was 4.0 years. We estimated the mean trajectories of the Beck Depression Inventory scores using latent-class growth-curve analysis. We identified four distinctive trajectories of depressive symptoms in both sex. The probabilities of group membership were 35.1% (n=2374) in minimal, 47.4% (n=4545) in persistent-mild, 14.4% (n=987) in persistent-moderate, and 3.0% (n=207) in persistent-severe in men, and 36.3% (n=1883), 50.0% (n=3069), 12.3% (n=601) and 1.5% (n=79) in women. We found significant increasing trend in the prevalence of metabolic abnormalities in more severe depressive trajectory. The adjusted odds ratios of persistent-severe were significantly incre...Continue Reading

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Citations

Apr 8, 2020·Issues in Mental Health Nursing·Jaewon Lee
Apr 3, 2018·Current Psychiatry Reports·Diego de la VegaLucas Giner
May 26, 2017·Osong Public Health and Research Perspectives·Jin Suk Ra, Hye Sun Kim
May 26, 2017·Osong Public Health and Research Perspectives·Hae-Wol Cho, Chaeshin Chu
Oct 15, 2019·Psychoneuroendocrinology·Alejandro de la Torre-LuquePilar Lopez-Garcia
Feb 20, 2021·Journal of Affective Disorders·A M PimentaA Sánchez-Villegas
Jul 23, 2021·Scientific Reports·Qian WuChen-Wei Pan

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