PMID: 6113731Jan 1, 1981Paper

Depressions in schizophrenia: some observations on prevalence, etiology, and treatment

Acta Psychiatrica Scandinavica. Supplementum
D A Johnson

Abstract

The results suggest that not only is depression a common symptom or syndrome in all stages of schizophrenia, but it is common even in the absence of treatment. However, there are a number of reasons for thinking that a proportion of patients on drugs may well suffer from drug related depressions, possibly 7.5-12.5 per cent. A difference in the effect upon mood, in the acute schizophrenic state, between flupenthixol and fluphenazine, has already been suggested (Johnson & Malik (1975)). Current research (Johnson (1976, 1979)) suggests that regular neuroleptic maintenance therapy is necessary for many years, certainly for more than four years following the most recent relapse. It is therefore of particular importance to concern ourselves with all potential side-effects such as extrapyramidal symptoms, weight gain (Johnson & Breen (1979)) an tardive dyskinesia (Gibson (1978)), and to keep the patients on personalised dose regimes which can frequently be reduced with time, particularly over the first two years of treatment (Johnson (1975, 1977)). WE must equally be on our guard against unnecessary polypharmacy which ultimately increases the risks for an already greatly disadvantaged patient.

References

Nov 1, 1978·Archives of General Psychiatry·S G SirisJ P Docherty
May 1, 1979·Acta Psychiatrica Scandinavica·D A Johnson, M Breen
Dec 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·D A Johnson
Oct 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·A C Gibson
May 1, 1975·The British Journal of Psychiatry : the Journal of Mental Science·D A Johnson
Sep 6, 1969·British Medical Journal·R De Alarcon, M W Carney

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Citations

Apr 7, 2005·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Jul 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Jul 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·S G SirisJ M Alvir
Aug 2, 2005·Schizophrenia Research·W Wolfgang FleischhackerUNKNOWN EUFEST Steering Committee
Dec 5, 2012·Journal of Behavior Therapy and Experimental Psychiatry·J J RicarteL Ros
Nov 8, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hans-Jürgen Möller

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