Depressive and anxiety disorders and risk of subclinical atherosclerosis Findings from the Netherlands Study of Depression and Anxiety (NESDA)

Journal of Psychosomatic Research
Adrie SeldenrijkBrenda W J H Penninx

Abstract

Current evidence regarding the association between psychopathology and subclinical atherosclerosis show inconsistent results. The present study examined whether subclinical atherosclerosis was more prevalent in a large cohort of persons with depressive or anxiety disorders as compared to non-depressed and non-anxious controls. Baseline data from the Netherlands Study of Depression and Anxiety were used, including 2717 persons, free of clinical cardiovascular disease. Participants had a DSM-IV-based current or remitted depressive (major depressive disorder, dysthymia) or anxiety (social phobia, generalized anxiety disorder, panic disorder, agoraphobia) disorder (n=2115) or were healthy controls (n=602). Additional clinical characteristics (severity, duration, age of onset and medication) were assessed. Ankle-brachial index (ABI) was used as a measure of vascular risk and was categorized as low (<or=0.90) and mildly low ABI (0.90-1.11) indicating subclinical atherosclerosis, and high ABI (>1.40), which was previously designated as a cardiovascular risk factor, reflecting arterial stiffness and wall calcification. As compared to normal controls, persons with current (i.e., past year) depressive, anxiety or comorbid depressive and ...Continue Reading

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Citations

Apr 25, 2013·Translational Psychiatry·N VogelzangsB W J H Penninx
Mar 16, 2016·Neural Plasticity·Vanja DuricLi-Lian Yuan
Dec 5, 2014·International Journal of Behavioral Medicine·Andreas R SchwerdtfegerEva-Maria Rathner
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Feb 20, 2021·International Journal of General Medicine·Zhaoqi Jia, Sen Li

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