Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events?

Epilepsia
Andres M KannerKimford J Meador

Abstract

To compare the effect of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on antiepileptic drug (AED)-related adverse events (AEs) in persons with epilepsy (PWE). The study included 188 consecutive PWE from five U.S. outpatient epilepsy clinics, all of whom underwent structured interviews (SCID) to identify current and past mood disorders and other current Axis I psychiatric diagnoses according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria. A diagnosis of SSDE was made in patients with total Beck Depression Inventory-II (BDI-II) scores >12 or the Centers of Epidemiologic Studies-Depression (CES-D) > 16 (in the absence of any DSM diagnosis of mood disorder. The presence and severity of AEs was measured with the Adverse Event Profile (AEP). Compared to asymptomatic patients (n = 103), the AEP scores of patients with SSDE (n = 26), MDE only (n = 10), anxiety disorders only (n = 21), or mixed MDE/anxiety disorders (n = 28) were significantly higher, suggesting more severe AED-related AEs. Univariate analyses revealed that having persistent seizures in the last 6 months and taking antidepressants was associated with more s...Continue Reading

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Citations

Nov 1, 2003·Epilepsy & Behavior : E&B·Jana E JonesKimford J Meador
Dec 5, 2003·Epilepsy & Behavior : E&B·Frank GilliamYvette Sheline
May 18, 2004·Epilepsy & Behavior : E&B·Joyce A CramerUNKNOWN Epilepsy Impact Project Group
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Feb 5, 2003·Seizure : the Journal of the British Epilepsy Association·K JagadheesanS Haque Nizamie
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May 7, 2014·Epilepsy & Behavior : E&B·Jong-Geun SeoSung-Pa Park
Jun 19, 2014·Epilepsy Currents·Rochelle Caplan
Mar 22, 2014·Current Neurology and Neuroscience Reports·Heidi M Munger Clary
Jan 20, 2016·Nature Reviews. Neurology·Andres M Kanner
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Jan 7, 2020·Journal of Pediatric Psychology·Amelia J ScottMilena Gandy

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