Depressive-like behavior, its sensitization, social buffering, and altered cytokine responses in rhesus macaques moved from outdoor social groups to indoor housing

Social Neuroscience
Michael B HennessyJ P Capitanio

Abstract

Psychosocial stressors appear to promote the onset of depressive illness through activation and sensitization of inflammatory mechanisms. Here, adult male rhesus monkeys brought from large outdoor social groups to indoor housing for 8 days reliably exhibited a hunched, depressive-like posture. When rehoused indoors a second 8 days about 2 weeks later, monkeys housed alone, but not those with an affiliative partner, showed sensitization of the depressive-like hunched posture. Housing indoors also affected circulating pro-inflammatory cytokines: IL-1β showed increased responsiveness to immune challenge, and IL-1β and TNF-α showed reduced suppression by dexamethasone. Sensitivity of the anti-inflammatory cytokine IL-10 to immune challenge exhibited a relative increase from the first to the second round of indoor housing in animals housed in pairs, and a relative decrease in animals housed alone. Cytokine levels during indoor housing were positively correlated with duration of depressive-like behavior. Plasma cortisol levels increased but did not differentiate housing conditions or rounds. Results demonstrate a rapid induction and sensitization of depressive-like behavior to indoor individual housing, social buffering of sensitizat...Continue Reading

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Citations

Feb 14, 2016·Social Neuroscience·Megan R Gunnar, Regina M Sullivan
Jan 23, 2019·Frontiers in Behavioral Neuroscience·Michael B HennessyTerrence Deak
Jan 10, 2020·American Journal of Primatology·Rhonda P MacAllisterKristine Coleman
Nov 30, 2019·American Journal of Primatology·Lauren J WooddellBrenda McCowan
Oct 3, 2020·Neuroscience and Biobehavioral Reviews·Eliza Bliss-Moreau, Peter H Rudebeck
Nov 13, 2017·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Marc N JarczokJulian F Thayer
Apr 12, 2021·Primates; Journal of Primatology·Valeria AlbaneseGiovanna Marliani
Apr 16, 2021·Frontiers in Behavioral Neuroscience·Lesly C CenicerosErin L Kinnally
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Andrea PolancoGeorgia Mason

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