Depressive symptomatology in young adults with a history of MDMA use: a longitudinal analysis

Journal of Psychopharmacology
Russel S FalckRobert G Carlson

Abstract

Research suggests that methylenedioxymethamphetamine (MDMA)/;ecstasy' can cause serotonin depletion as well as serotonergic neurodegradation that may result in depression. This longitudinal study used the Beck Depression Inventory (BDI-II) to assess depressive symptomatology every six months over a two-year period among a community sample of young adult MDMA/;ecstasy' users (n = 402). Multilevel growth modeling was used to analyze changes in BDI scores. Between baseline and 24 months, the mean BDI score declined from 9.8 to 7.7. Scores varied significantly across individuals at baseline and declined at a rate of 0.36 points every six months. Persons with higher baseline scores were more likely to have their scores decrease over time. Several factors were significantly associated with score levels, independent of time: gender - men's scores were lower than women's; ethnicity - whites' scores were lower than those of non-whites; education - persons with at least some university education had scores that were lower than those without any college experience; benzodiazepines - current users' scores were higher than non-users'; opioids - current users' scores were higher than non-users'; and cumulative ecstasy use - people who had us...Continue Reading

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Citations

Feb 11, 2011·Journal of Psychoactive Drugs·Raminta DaniulaityteBrenda M Booth
Jun 19, 2018·Culture, Health & Sexuality·Kristin M Kostick, Jean J Schensul
Dec 25, 2010·Addiction·John E FiskFlorentia Hadjiefthyvoulou
Jan 31, 2021·Pharmacology, Biochemistry, and Behavior·M L Shawn Bates, Keith A Trujillo

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