Depressive symptoms and proinflammatory cytokines across the perinatal period in African American women

Journal of Psychosomatic Obstetrics and Gynaecology
Emma Robertson BlackmoreJan A Moynihan

Abstract

Comparatively few studies have examined the biological mechanisms that may underlie the reported racial disparities in antenatal and postpartum depression. To examine the associations among race, depressive symptoms and the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α across the perinatal period in a diverse sample of healthy pregnant women at elevated psychosocial risk. 171 subjects were enrolled. Women were interviewed and blood samples drawn at 18 and 32 weeks gestation and 6 weeks and 6 months postpartum. Depressive symptoms were measured using the Edinburgh Postnatal Depression Scale. Serum levels of IL-6 and TNF-α were assayed using high sensitivity enzyme-linked immunosorbent assay kits. Compared with non-African American (AA) women, AA women had significantly higher levels of IL-6 (est. diff = 0.521, p = 0.02, confidence interval (CI): 0.088-0.954) but not TNF-α across all time points (est. diff = -0.060, p = 0.80, CI: -0.517 to 0.397). IL-6 was not associated with depressive symptoms but differences in IL-6 were accounted for by greater Body Mass Index in AA women. Compared with non-AA women, AA women entered pregnancy with elevated inflammatory cytokine levels that persisted across th...Continue Reading

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Citations

Nov 26, 2015·Journal of Psychosomatic Obstetrics and Gynaecology·Chelsea MorrisonBeth A Bailey
Mar 22, 2016·Journal of Affective Disorders·Emma Robertson BlackmoreThomas G O'Connor
Nov 26, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Francis E LotrichRobert K McNamara
Apr 12, 2016·Journal of Reproductive Immunology·Andrew S BossickAndrea E Cassidy-Bushrow
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Jan 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Nebal El TanboulyEssam Abdel-Sattar
Sep 30, 2014·CNS Spectrums·Crystal Edler SchillerDavid R Rubinow
Jul 22, 2016·Maternal and Child Health Journal·Kimberly Schmitt McKeeI Diana Fernandez
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Dec 12, 2019·Metabolic Brain Disease·Sherry A FergusonSumit Sarkar
Mar 9, 2021·Journal of Pregnancy·Toni SpenceEmeir M McSorley
Aug 31, 2021·Western Journal of Nursing Research·Giurgescu CStemmer P

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