Depressive Symptoms Clusters and Insulin Resistance: Race/Ethnicity as a Moderator in 2005-2010 NHANES Data

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine
Elizabeth A VranyJesse C Stewart

Abstract

Although depression has been linked to insulin resistance, few studies have examined depressive symptom clusters. We examined whether certain depressive symptom clusters are more strongly associated with insulin resistance in a nationally representative sample, and we evaluated potential moderators and mediators. Respondents were 4487 adults from NHANES 2005-2010. Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9), and insulin resistance was indexed by the homeostatic model assessment (HOMA) score. Positive relationships between PHQ-9 total, somatic, and cognitive-affective scores and HOMA score were detected (ps <0.001). In a simultaneous model, the somatic (p = 0.017), but not the cognitive-affective (p = 0.071), score remained associated with HOMA score. We observed evidence of (a) moderation by race/ethnicity (relationships stronger in non-Hispanic Whites) and (b) mediation by body mass and inflammation. The depressive symptoms-insulin resistance link may be strongest among non-Hispanic Whites and may be driven slightly more by the somatic symptoms.

References

Jul 22, 1999·The New England Journal of Medicine·P R Shepherd, B B Kahn
Aug 23, 2000·The Journal of Clinical Investigation·H N Ginsberg
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Jul 9, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·T M Wallace, D R Matthews
Oct 16, 2002·Journal of Psychosomatic Research·Janice K Kiecolt-Glaser, Ronald Glaser
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Nov 25, 2004·Diabetes Care·Susan A Everson-RoseKaren A Matthews
Jan 22, 2005·American Heart Journal·Phillippa J MirandaJohn R Guyton
Apr 6, 2005·The American Journal of Medicine·Lynn E SullivanPatrick G O'Connor
Jun 15, 2005·Psychosomatic Medicine·Kenneth E FreedlandJudith A Skala
Nov 30, 2005·International Journal of Geriatric Psychiatry·Celia F HybelsK Ranga Rama Krishnan
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Jul 1, 2006·Journal of General Internal Medicine·Frederick Y HuangRobert L Spitzer
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Kristina M Utzschneider, Steven E Kahn
Dec 7, 2006·Annals of the New York Academy of Sciences·Alexandros N VgontzasGeorge P Chrousos
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Jan 20, 2007·International Journal of Geriatric Psychiatry·Koen Van der KooyAartjan Beekman
Jul 13, 2007·Diabetes Care·Linda A BarbourJacob E Friedman
Sep 25, 2007·General Hospital Psychiatry·Karin A WittkampfHenk C van Weert
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Sherita Hill GoldenConstantine Lyketsos
Jul 24, 2008·Journal of General Internal Medicine·Wayne KatonMichael Schoenbaum
Sep 9, 2008·Endocrinology and Metabolism Clinics of North America·Emily Jane GallagherEddy Karnieli
Nov 27, 2008·Diabetes Care·Briana MezukSherita Hill Golden
Feb 3, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·L FisherU Masharani
Feb 4, 2009·Psychosomatic Medicine·M Bryant HowrenJerry Suls
May 7, 2009·Brain, Behavior, and Immunity·Jesse C StewartThomas W Kamarck
Oct 31, 2009·Diabetes Care·Dolly O BaliunasJürgen Rehm
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Mar 3, 2010·Archives of General Psychiatry·Floriana S LuppinoFrans G Zitman
Aug 17, 2010·Diabetologia·A NouwenUNKNOWN European Depression in Diabetes (EDID) Research Consortium
Apr 9, 2011·Psychoneuroendocrinology·James K RustadCharles B Nemeroff
Jul 5, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Isobel M CameronIan C Reid
Oct 4, 2011·Clinical Psychology Review·Brenna N RennDaniel L Segal
Dec 21, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Laura ManeaDean McMillan

❮ Previous
Next ❯

Citations

Sep 9, 2016·Frontiers in Psychiatry·Shervin Assari, Maryam Moghani Lankarani
May 12, 2017·Depression and Anxiety·Stephen M SchuellerDavid C Mohr
May 13, 2017·Behavioral Sciences·Shervin Assari, Cleopatra Howard Caldwell
Apr 4, 2017·American Journal of Epidemiology·Brittanny M PolankaJesse C Stewart
Jan 21, 2017·Frontiers in Aging Neuroscience·Shervin Assari, Maryam M Lankarani
Mar 30, 2021·Informatics for Health & Social Care·Brendan Loo GeeKathleen M Griffiths

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Ecosse L LamoureuxGwen Rees
European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology
Muna H HammashDebra K Moser
© 2021 Meta ULC. All rights reserved