Depressive symptoms, frailty, and adverse outcomes among kidney transplant recipients

Clinical Transplantation
Jonathan M KonelMara A McAdams-DeMarco

Abstract

Depressive symptoms and frailty are each independently associated with morbidity and mortality in kidney transplant (KT) recipients. We hypothesized that having both depressive symptoms and frailty would be synergistic and worse than the independent effect of each. In a multicenter cohort study of 773 KT recipients, we measured the Fried frailty phenotype and the modified 18-question Center for Epidemiologic Studies-Depression Scale (CES-D). Using adjusted Poisson regression and survival analysis, we tested whether depressive symptoms (CES-D score > 14) and frailty were associated with KT length of stay (LOS), death-censored graft failure (DCGF), and mortality. At KT admission, 10.0% of patients exhibited depressive symptoms, 16.3% were frail, and 3.6% had both. Recipients with depressive symptoms were more likely to be frail (aOR = 3.97, 95% CI: 2.28-6.91, P < 0.001). Recipients with both depressive symptoms and frailty had a 1.88 times (95% CI: 1.70-2.08, P < 0.001) longer LOS, 6.20-fold (95% CI:1.67-22.95, P < 0.01) increased risk of DCGF, and 2.62-fold (95% CI:1.03-6.70, P = 0.04) increased risk of mortality, compared to those who were nonfrail and without depressive symptoms. There was only evidence of synergistic effect o...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brenda R HemmelgarnWilliam A Ghali
Apr 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fabienne DobbelsBertram L Kasiske
Nov 26, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lilla SzeifertMarta Novak
Feb 16, 2012·International Psychogeriatrics·Aine M Ní MhaoláinBrian Lawlor
Feb 22, 2012·Archives of Surgery·Jacqueline M Garonzik-WangDorry L Segev
Jun 27, 2012·Archives of Internal Medicine·Yeran BaoKirsten L Johansen
Sep 11, 2012·International Journal of Geriatric Psychiatry·Philip D St JohnPatrick R Montgomery
May 29, 2013·Journal of the American Geriatrics Society·Mara A McAdams-DeMarcoDorry L Segev
Jun 5, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A McAdams-DeMarcoD L Segev
Oct 26, 2013·Journal of the American Society of Nephrology : JASN·Kirsten L JohansenGlenn M Chertow
Jun 28, 2014·American Journal of Nephrology·Li FanDaniel E Weiner
Oct 17, 2014·Aging & Mental Health·Cristina BuiguesOmar Cauli
Nov 2, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A McAdams-DeMarcoD L Segev
Nov 14, 2014·Transplantation·Mara A McAdams-DeMarcoDorry L Segev
Sep 30, 2015·Journal of the American Geriatrics Society·Mara A McAdams-DeMarcoDorry L Segev
Nov 18, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Mara A McAdams-DeMarcoStephen M Sozio
May 3, 2016·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Ansley StanfillAnn Cashion
Oct 19, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Patrick J BrownSteven P Roose
Oct 26, 2016·Transplantation·Mara A McAdams-DeMarcoDorry L Segev
Jul 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J NastasiD L Segev
Sep 9, 2017·Transplantation·Mara A McAdams-DeMarcoDorry L Segev
Jan 18, 2018·KI Reports·Mara A McAdams-DeMarcoDorry L Segev

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Citations

Mar 8, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Akihiro KosokuTatsuya Nakatani
Aug 21, 2020·JCI Insight·Reyhan WestbrookPeter M Abadir
May 19, 2019·BMC Nephrology·Prakriti ShresthaMara A McAdams-DeMarco
Nov 27, 2019·Current Transplantation Reports·Mara A McAdams-DeMarcoDorry L Segev
Jul 26, 2019·Transplantation·Mara A McAdams-DeMarcoUNKNOWN AST Kidney Pancreas Community of Practice Workgroup
Jul 22, 2020·Langenbeck's Archives of Surgery·Evelien E QuintRobert A Pol
Oct 22, 2019·Therapeutic Advances in Chronic Disease·Patrick Yihong WuKuan-Yu Hung
Oct 21, 2020·International Psychogeriatrics·Marta Carolina Ruiz-GraoPedro Abizanda
Dec 15, 2020·Advances in Chronic Kidney Disease·Tessa K NovickLilia Cervantes
Apr 23, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Maria Irene BelliniFederico Bilotta
May 27, 2021·Transplantation Direct·Evelien E QuintRobert A Pol
Jun 21, 2019·Current Opinion in Organ Transplantation·Joanna SchaenmanMaricar Malinis

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