Depressive symptoms in heart failure: Independent prognostic factor or marker of functional status?

Journal of Psychosomatic Research
Hermann FallerC E Angermann

Abstract

The prognostic potential of depressive symptoms independent of somatic features of heart failure severity has repeatedly been demonstrated. However, patient-reported functional status has rarely been accounted for in these studies. Thus, it has remained unclear to what extent the predictive power of depressive symptoms may mirror functional status. We therefore aimed to evaluate the prognostic value of depressive symptoms adjusting for patient-reported functional status in a large, well-characterized sample of patients with systolic heart failure. Eight hundred sixty-three patients, 67±12 years old, 72% men, and 42% with New York Heart Association functional classes III/IV, who participated in the extended Interdisciplinary Network Heart Failure (INH) study were investigated. We assessed depressive symptoms using the Patient Health Questionnaire (PHQ-9) and patient-reported functional status with the Kansas City Cardiomyopathy Questionnaire (KCCQ). Data on survival was obtained after a follow-up of 18 months (100% complete). Depressive symptoms predicted mortality risk (HR per PHQ-9 scale point=1.07, 95% CI 1.04-1.09, p<.001), even after adjustment for heart failure severity and co-morbidities (HR=1.04, 95% CI 1.01-1.07, p=.017...Continue Reading

References

Apr 12, 2000·Journal of the American College of Cardiology·C P GreenJ A Spertus
Oct 29, 2005·Patient Education and Counseling·Catherine BaneJames C McElnay
Nov 6, 2007·Journal of Psychosomatic Research·Hermann FallerChristiane E Angermann
Nov 27, 2008·JAMA : the Journal of the American Medical Association·Mary A WhooleyWarren S Browner
Jan 1, 2009·Stress : the International Journal on the Biology of Stress·Angela J Grippo, Alan Kim Johnson
Sep 1, 2009·International Journal of Cardiology·Christiane E AngermannUNKNOWN Competence Network Heart Failure
Nov 27, 2010·Heart Failure Clinics·Kenneth E FreedlandMichael W Rich
May 3, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoko KatoRyozo Nagai
Jun 23, 2011·Circulation. Cardiovascular Quality and Outcomes·Larry A AllenJohn A Spertus
Feb 22, 2012·International Journal of Cardiology·Nicole LossnitzerUNKNOWN Competence Network Heart Failure
Sep 20, 2012·European Journal of Heart Failure·Tialda HoekstraIvonne Lesman-Leegte
Dec 25, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Marion SchowalterChristiane E Angermann
Apr 30, 2013·Circulation. Heart Failure·Alanna M ChamberlainVéronique L Roger
Feb 4, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Kyoung Suk LeeDebra K Moser

❮ Previous
Next ❯

Citations

May 24, 2016·Journal of Psychosomatic Research·J C Tolentino, S L Schmidt
Jan 8, 2019·PLoS Neglected Tropical Diseases·Christoph NikendeiMarija Stojkovic
Apr 15, 2016·The Journal of Cardiovascular Nursing·Stephanie A HookerDavid B Bekelman
Nov 28, 2020·European Journal of Clinical Investigation·Roy C Ziegelstein, Brett D Thombs
Aug 27, 2019·Journal of Psychosomatic Research·Mira-Lynn ChavanonChristoph Herrmann-Lingen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Journal of the American College of Cardiology
Paul A HeidenreichCardiovascular Outcomes Research Consortium
Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Paola Di Giulio, Paola Di Giulio
© 2021 Meta ULC. All rights reserved