Depressive symptoms increase the likelihood of cognitive impairment in elderly people with subclinical Alzheimer pathology

Dementia and Geriatric Cognitive Disorders
Elizabeth J Milwain, Zsuzsanna Nagy

Abstract

The objective of this study was to investigate whether the presence of depressive symptoms influences the clinical expression of Alzheimer's pathology. We have analysed the relationships between the severity of Alzheimer's pathology and cognitive decline in two patient groups defined by the presence or absence of depressive symptoms. The study included 89 subjects who participated in a longitudinal research programme prior to death, underwent post-mortem examination and were found to have only Alzheimer-type pathology in their brains, ranging in severity from the entorhinal to neocortical stages. Our results indicate that depressive symptoms did not influence cognition in the early (entorhinal) stages of Alzheimer's disease (AD; where cognition was good regardless of whether or not there was evidence for depressive symptoms) or in the late (neocortical) stages (where cognition was poor regardless of whether or not there was evidence for depression). However, in the intermediate (limbic) stages, patients with depressive symptoms had significantly worse cognitive performance (mean CAMCOG of 32) than those who did not (mean CAMCOG of 73). We conclude that depressive symptoms may contribute to the cognitive decline of AD patients i...Continue Reading

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Citations

Jul 27, 2012·Translational Psychiatry·S E ArnoldL M Shaw
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michael A RappVahram Haroutunian
Oct 20, 2009·European Journal of Pharmacology·Filippo CaraciFilippo Drago
Nov 20, 2012·Neuromolecular Medicine·Zhiyou CaiAnna Ratka
Jul 7, 2005·International Journal of Geriatric Psychiatry
Oct 16, 2019·Frontiers in Pharmacology·Tommaso CassanoSilvana Gaetani
Jun 4, 2021··Bashar Mohammad Abdallah_QasaimehAmmar Abdallah

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