Depressive Symptoms Mediate the Effect of HIV-Related Stigmatization on Medication Adherence Among HIV-Infected Men Who Have Sex with Men

AIDS and Behavior
Luke D MitzelMichael P Carey

Abstract

This study tested the hypothesis that depressive symptoms would mediate the association of HIV-related stigma to medication adherence. We recruited HIV-infected men who have sex with men (MSM; N = 66; 66 % White, 23 % African-American) from an outpatient infectious disease clinic, and asked them to complete self-report measures. Mediational analyses showed that depressive symptoms fully mediated the association between HIV-related stigma and adherence. That is, stigma-related experiences were positively associated with depressive symptoms and negatively associated with adherence, and, in the final model, depressive symptoms remained a significant correlate of adherence while stigma did not. A test of the indirect effect of stigma on adherence through depressive symptoms was also significant (unstandardized b = -0.19; bootstrap 95 % CI -0.45 to -0.01). These results highlight the importance of treating depressive symptoms in interventions aiming to improve medication adherence among HIV-infected MSM.

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Citations

Sep 5, 2018·Reviews on Recent Clinical Trials·Aven SidhuOsamah Alenezi
Dec 8, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Victoria C Seghatol-EslamiBulent Turan
Dec 19, 2018·AIDS and Behavior·Ying Chew TeeJeffrey A Wickersham
Apr 8, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Seth KalichmanKatherine R Thorson
Jun 20, 2020·Current HIV/AIDS Reports·Katherine G Quinn, Dexter R Voisin
Dec 10, 2020·Perspectives in Psychiatric Care·Servet ÖztürkCanan Ağalar

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