PMID: 9426042Jan 13, 1998Paper

Depressor action of insulin on skeletal muscle vasculature: a novel mechanism for postprandial hypotension in the elderly

Journal of the American College of Cardiology
Mark T KearneyI A Macdonald

Abstract

We sought to assess the role of insulin in postprandial blood pressure regulation in the elderly. Insulin is both a positive inotropic and chronotropic hormone that also vasodilates skeletal muscle vasculature. Insulin may thus mediate aspects of postprandial cardiovascular homeostasis. Ten healthy elderly subjects were studied in the fasting state on three separate days. After baseline supine hemodynamic and neurohumoral measurements were taken (cardiac output and superior mesenteric artery blood flow were measured using Doppler ultrasound, and calf blood flow was measured using venous occlusion plethysmography), subjects ate on one occasion a 2.5-MJ high carbohydrate meal and on the other two occasions, an isoenergetic high fat meal. One high fat meal was accompanied by an insulin infusion reproducing the plasma insulin profile seen after a high carbohydrate meal while maintaining the glycemic profile seen after a high fat meal alone. After meal ingestion, measurements were repeated every 20 min for 2 h. After the three meals, there were similar increments in cardiac output and heart rate. After the high carbohydrate meal and high fat meal with insulin, mean arterial blood pressure fell by between 8 to 10 mm Hg, but did not c...Continue Reading

References

Jan 1, 1979·Ultrasound in Medicine & Biology·R W Gill
Oct 1, 1978·Clinical Science and Molecular Medicine·D J Ewing
Oct 1, 1976·Journal of Applied Physiology·E A McGuireM Berman
Feb 1, 1975·Circulation Research·E G LakattaM L Weisfeldt
Jun 1, 1991·The Journal of Clinical Investigation·E A AndersonA L Mark
Jul 1, 1991·Journal of Gerontology·L A LipsitzJ S Koestner
Nov 1, 1989·The Journal of Clinical Investigation·C BerneF Niklasson
Nov 1, 1989·Journal of the American Geriatrics Society·R W Jansen, W H Hoefnagels
Jun 1, 1989·British Heart Journal·H KelbaekJ Godtfredsen
Jan 1, 1988·Annual Review of Physiology·B G Wallin, J Fagius
Nov 1, 1987·The American Journal of Cardiology·R W JansenW H Hoefnagels
May 1, 1985·Journal of Neuroscience Methods·I A Macdonald, D M Lake
Nov 1, 1972·The American Journal of Physiology·J W FaraR R Sonnenschein
Nov 1, 1972·The Journal of Clinical Investigation·R P ZollerD D Heistad
Oct 1, 1971·Circulation Research·B GribbinR Peto
Nov 17, 1983·The New England Journal of Medicine
Jul 14, 1983·The New England Journal of Medicine·L A LipsitzJ W Rowe
Aug 1, 1995·Clinical Science·H S CoxM D Esler
Dec 1, 1994·The Journal of Clinical Investigation·U ScherrerP Nicod
Jul 1, 1953·The Journal of Physiology·R J WHITNEY
May 1, 1963·British Medical Bulletin·A D GREENFIELDJ F MOWBRAY

❮ Previous
Next ❯

Citations

Aug 22, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A S ObermanL A Lipsitz
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J E Morley
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L C VloetR W Jansen
Mar 4, 2014·Rinshō shinkeigaku = Clinical neurology·Hirokuni SakimaYusuke Ohya
Mar 19, 2014·Journal of the American Medical Directors Association·Laurence G TrahairKaren L Jones
Aug 19, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nataša VavicMaria Marinozzi
Feb 18, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jun WatanabeKeiichi Nishimaki
Apr 17, 2002·The Journal of Physiology·Deirdre O'DonovanKaren Louise Jones
Mar 3, 2010·The American Journal of Medicine·Gina L LucianoMichael B Rothberg
Oct 13, 2009·Biochimica Et Biophysica Acta·Helen ImrieMark Kearney
Apr 5, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·S B WheatcroftM T Kearney
May 31, 2012·Journal of Clinical Nursing·Jung Tae Son, Eunjoo Lee
Apr 8, 2014·Parkinsonism & Related Disorders·Tadashi UmeharaHisayoshi Oka
Nov 25, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lilian C M VloetRené W M M Jansen
May 31, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I L WilliamsM T Kearney
Feb 23, 2017·World Journal of Critical Care Medicine·Thu An NguyenAdam M Deane
Oct 3, 2006·Current Opinion in Anaesthesiology·G M Hall, R Ruggier
Oct 22, 2019·Spinal Cord Series and Cases·Clara FarrehiMichael Stillman
Oct 16, 2007·Experimental Physiology·Mark T KearneyStephen B Wheatcroft
Feb 18, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kenneth M MaddenGraydon S Meneilly
Mar 9, 2019·International Journal of Environmental Research and Public Health·Masahiko HashizumeHideyuki Shiotani
Feb 27, 2016·Journal of Applied Physiology·Masako Yamaoka EndoYoshiyuki Fukuba
Aug 30, 2020·Spinal Cord Series and Cases·Clara FarrehiMichael Stillman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.