PMID: 7543948Aug 1, 1995Paper

Deprivation of dietary nucleotides results in a transient decrease in acid-soluble nucleotides and RNA concentration in rat liver

The Journal of Nutrition
A López-NavarroA Sánchez-Pozo

Abstract

This study examines the contribution of dietary nucleotides to liver nucleotide pools in rats. Liver acid-soluble nucleotides, DNA and RNA concentrations were monitored in two groups of rats fed either a diet supplemented with nucleotides or a diet free of nucleotides for 3 wk. Significantly lower concentrations of ATP, ADP, GTP and CDP as well as of RNA were found after 1 wk in the rats fed a nucleotide-free diet compared with those fed the nucleotide-supplemented diet; concentrations remained lower after 2 wk except for ATP and ADP. No changes over time were observed in the rats fed the nucleotide-supplemented diet. Between wk 2 and 3 an increase in both acid-soluble nucleotides and RNA was observed in the rats fed the nucleotide-free diet, reaching the values found in the rats fed the nucleotide-supplemented diet. These findings, which indicate that dietary nucleotides are utilized at least in part by the liver to maintain the cell nucleotide pools and that diets devoid of nucleotides affect hepatic nucleotide metabolism and RNA, support the hypothesis that liver nucleotide metabolism is modulated by the availability of dietary nucleotides.

Citations

Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·F B Rudolph, C T Van Buren
Mar 16, 2002·The British Journal of Nutrition·A Sánchez-Pozo, A Gil
Jul 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Alexandra ArnaudAngel Gil
Oct 1, 1996·The British Journal of Nutrition·A T López-NavarroA Sánchez-Pozo
Oct 1, 1996·The British Journal of Nutrition·G K Grimble
Dec 16, 1998·The British Journal of Nutrition·B KoletzkoS Strobel
Dec 13, 2000·Gastroenterology·R ValdésM Pastor-Anglada
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohamed E SulimanPeter Stenvinkel

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