Depth of submucosal invasion does not predict lymph node metastasis and survival of patients with esophageal carcinoma.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Rami J BadreddineKenneth K Wang

Abstract

There is controversy over the outcomes of esophageal adenocarcinoma with superficial submucosal invasion. We evaluated the impact of depth of submucosal invasion on the presence of metastatic lymphadenopathy and survival in patients with esophageal adenocarcinoma. Pathology reports of esophagectomy samples collected from 1997 to 2007 were reviewed. Specimens from patients with esophageal adenocarcinoma and submucosal invasion were reviewed and classified as superficial (upper 1 third, sm1) or deep (middle third, sm2 or deepest third, sm3) invasion. Outcomes studied were presence of metastatic lymphadenopathy and overall survival. Variables of interest were analyzed as factors that affect overall and cancer-free survival using Cox proportional hazards modeling. A multivariate model was constructed to establish independent associations with survival. The study included 80 patients; 31 (39%) had sm1 carcinoma, 23 (29%) had sm2 carcinoma, and 26 (33%) had sm3 carcinoma. Superficial and deep submucosal invasion were associated with substantial rates of metastatic lymphadenopathy (12.9% and 20.4%, respectively). The mean follow-up time was 40.5 +/- 4 months and the mean overall unadjusted survival time was 53.8 +/- 4.1 months. Factor...Continue Reading

Citations

Feb 2, 2012·Der Pathologe·G B Baretton, D E Aust
Sep 14, 2012·Therapeutic Advances in Gastroenterology·Shanmugarajah Rajendra, Prateek Sharma
Dec 21, 2013·Current Gastroenterology Reports·Gary W Falk
Mar 19, 2014·Current Treatment Options in Gastroenterology·Shanmugarajah Rajendra, Prateek Sharma
Jul 18, 2014·Journal of the National Cancer Institute·Ryan P MerkowDavid J Bentrem
Jun 6, 2013·Journal of Gastroenterology·L Max Almond, Hugh Barr
May 3, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·O Pech, C Ell
Jan 30, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hendrik MannerChristian Ell
Apr 18, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sachin WaniPrateek Sharma
Oct 18, 2011·Gastrointestinal Endoscopy·Jianmin TianKenneth K Wang
Oct 31, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jon M DavisonKatie S Nason
Sep 27, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Joshua A BoysSteven R DeMeester
Oct 19, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elfriede Bollschweiler, Arnulf H Hölscher
Nov 30, 2010·Gastrointestinal Endoscopy Clinics of North America·Jennifer ChennatIrving Waxman
Jun 15, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vikneswaran NamasivayamGanapathy A Prasad
Mar 10, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H MannerC Ell
May 11, 2015·Gastroenterology·Joel H Rubenstein, Nicholas J Shaheen
Aug 27, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniela MolenaSteven R DeMeester
Apr 26, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael S LandauJon M Davison
Jul 21, 2015·Critical Reviews in Food Science and Nutrition·Daotong LiFang Chen
Sep 7, 2011·Nature Reviews. Gastroenterology & Hepatology·Aparna Repaka, Amitabh Chak
Oct 8, 2013·Annals of Surgery·Dietmar LorenzChristian Ell
Oct 31, 2013·Annals of Surgery·Arnulf H Hölscher, Elfriede Bollschweiler
Nov 4, 2015·The American Journal of Gastroenterology·Nicholas J ShaheenUNKNOWN American College of Gastroenterology
Feb 27, 2014·Clinical Endoscopy·Javier Aranda-HernandezNorman Marcon
Aug 13, 2020·Therapeutic Advances in Gastrointestinal Endoscopy·Oliver Pech, Saleh A Alqahtani
Jan 5, 2019·Annals of Surgical Oncology·Fariha H RamayMelanie A Edwards
Nov 30, 2010·Gastrointestinal Endoscopy Clinics of North America·Oliver PechChristian Ell
Jan 1, 2010·Seminars in Thoracic and Cardiovascular Surgery·Hendrik MannerChristian Ell

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