Depth-resolved blood oxygen saturation assessment using spectroscopic common-path Fourier domain optical coherence tomography.

IEEE Transactions on Bio-medical Engineering
Xuan Liu, Jin U Kang

Abstract

Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two issues that could significantly improve the quantitative assessment of blood oxygen saturation level. First, we have implemented a spectral normalization technique to eliminate the spectral modulation induced by the wavelength-distance-dependent point spread function (PSF) of OCT's. Second, to reduce the spectral speckle noise due to the highly scattering blood, we have implemented a spatial low-pass filter to the 2-D OCT dataset consisting of spectra obtained at different lateral positions. We have assessed the effectiveness of these methods using common-path OCT system. Results showed that we were able to extract unambiguous depth-resolved, SO(2)-dependent spectroscopic information from 1-D and 2-D OCT images, which could be used to accurately assess the SO(2) level.

References

Sep 18, 2007·Journal of Biomedical Optics·Larry KagemannJoel S Schuman
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Jul 11, 2005·Optics Express·Chenyang XuStephen Boppart
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Citations

May 13, 2011·Analytical and Bioanalytical Chemistry·Julia WaltherEdmund Koch
Oct 11, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Jing MenChao Zhou
Jul 9, 2016·Journal of Biomedical Optics·Hyeong Soo NamHongki Yoo
Nov 15, 2011·Biomedical Optics Express·Xuan LiuJin U Kang
Jan 13, 2017·International Journal of Retina and Vitreous·Prateep PhadikarDean Eliott
Dec 10, 2014·Journal of Biomedical Optics·Jianbing XuKenneth K Y Wong
May 9, 2015·Physics in Medicine and Biology·Jina KimAdam Wax

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