PMID: 7516458Jan 1, 1993Paper

Deranged activity of the CD44 gene and other loci as biomarkers for progression to metastatic malignancy

Journal of Cellular Biochemistry. Supplement
D Tarin, Y Matsumura

Abstract

About one in three people in modern industrialised countries die of the consequences of malignant tumours or are found to carry an unsuspected one at the time of autopsy. Early resection of such lesions and appropriate adjuvant therapy is very effective in curing the disease. There is therefore a strong clinical incentive to find effective methods of early diagnosis, assessment of prognosis and treatment of neoplastic lesions and research on this topic is directed at a numerically significant medical problem. Recently it has been found that many human tumours show severe abnormalities in the expression of the CD44 gene which increase with progression to metastatic malignancy. By alternative splicing mechanisms this gene codes for a family of heavily glycosylated cell surface proteins involved in many important cellular activities. In neoplasia there is gross overexpression of various products of the gene associated with disorderly splicing, which can be detected in clinical samples with the sensitive technique of reverse transcription-polymerase chain reaction (RT-PCR). These disturbances begin early in the neoplastic process and can be detected in very small biopsy samples. It has also been shown that it is possible to achieve...Continue Reading

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Citations

Jul 12, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·David Tarin
Jan 14, 2012·PloS One·Abirami RajarajanEdward W Odell
Jul 20, 2002·The Journal of Urology·Mazen A GhanemRien J M Nijman
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·J T PriceE C Kohn
May 1, 1996·The Journal of Pathology·J MathewA D Burt
Apr 17, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Abirami RajarajanEdward W Odell

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