Deranged hydrophobic barrier of the rat gastroduodenal mucosa after parenteral nonsteroidal anti-inflammatory drugs

Gastroenterology
A LugeaJ R Malagelada

Abstract

Parenteral administration of nonsteroidal anti-inflammatory drugs (NSAIDs) may cause gastrointestinal mucosal lesions. The aim of this study was to investigate whether parenteral NSAIDs alter surface hydrophobicity of the gastroduodenal mucosa. Conscious rats received indomethacin or diclofenac subcutaneously at different doses (0.5-10 mg/kg). Surface hydrophobicity of gastric and duodenal mucosa was determined by contact angle measurement at various time points; mucosal prostaglandin synthesis and mucus phospholipid content were measured. Also, the effects of NSAIDs were studied in bile duct-ligated rats. A single 1-2-mg/kg dose significantly decreased hydrophobicity in the stomach and duodenum. The decrease was associated with a reduction in mucus phosphatidylcholine. In the duodenum, mucosal prostaglandin synthesis was restored 24 hours after NSAID dosing, but hydrophobicity was still decreased. There was no adaptation to long-term treatment. In bile duct-ligated rats, NSAIDs did not decrease gastric or duodenal hydrophobicity. Moreover, oral administration of bile from rats pretreated with parenteral NSAIDs significantly decreased mucosal hydrophobicity in untreated rats. Low-dose NSAIDs by parenteral route impair the physi...Continue Reading

Citations

Dec 15, 2010·International Journal of Molecular Sciences·Hannah SchneiderRobert Ehehalt
Nov 20, 2012·The Journal of Surgical Research·Elizabeth J DialLenard M Lichtenberger
Feb 27, 2007·Clinical Biochemistry·Michele PetruzzelliPiero Portincasa
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Ashkan FarhadiAli Keshavarzian
Aug 16, 2003·British Journal of Clinical Pharmacology·Simon Smale, Ingvar Bjarnason
Jan 27, 2006·European Journal of Clinical Investigation·N G VennemanK J van Erpecum
Dec 1, 2014·Medical Hypotheses·C M SpiesF Buttgereit
Oct 25, 2006·International Journal of Colorectal Disease·Sebastián VidelaJuan R Malagelada
Jan 20, 1999·European Journal of Clinical Investigation·A García-LafuenteJ Malagelada
Dec 8, 2006·Archives of Toxicology·Molly JacobIngvar Bjarnason
Apr 2, 2011·International Journal of Colorectal Disease·Annika BraunRobert Ehehalt
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y AkibaJ D Kaunitz
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Adrian Allen, Gunnar Flemström
Feb 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y AkibaJ D Kaunitz
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A LugeaJ R Malagelada
Oct 7, 2006·Current Opinion in Gastroenterology·L M Lichtenberger
Nov 28, 2000·Equine Veterinary Journal·M T EthellB A Hills
Mar 31, 2021·Journal of Gastroenterology and Hepatology·Naoki ShibuyaRyota Hokari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.