Deranged sodium to sudden death

The Journal of Physiology
Colleen E ClancyAntonio Zaza

Abstract

In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na(+) channel structure, function and regulation, and Na(+)/Ca(2+) exchange and Na(+)/K(+) ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na(+) in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na(+) homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na(+)-based processes leads to derangement in multiple cardiac components at the level of the c...Continue Reading

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Citations

Mar 21, 2016·The Journal of Physiology
Mar 17, 2015·The Journal of Physiology·Donald M Bers, Ye Chen-Izu
Oct 18, 2015·Journal of Molecular and Cellular Cardiology·Juan F GomezBeatriz Trenor
Apr 4, 2017·The Journal of Physiology·Donald M Bers, Ye Chen-Izu
Jun 20, 2017·The Journal of General Physiology·Frank B SachseWayne R Giles
Oct 11, 2017·Cardiovascular Research·Edoardo BerteroChristoph Maack
Apr 15, 2017·Circulation. Arrhythmia and Electrophysiology·Zhenjiang YangKatherine T Murray
Oct 9, 2018·European Heart Journal·Christoph MaackAlexandre Mebazaa
Oct 18, 2018·European Journal of Heart Failure·Vasco Sequeira, Christoph Maack
Jun 28, 2017·Journal of Cardiovascular Pharmacology·Alexander Burashnikov
Nov 9, 2018·Frontiers in Physiology·Nicolai M DolibaMary D Osbakken
Jan 31, 2020·The Journal of Physiology·Donald M BersYe Chen-Izu
Jul 16, 2020·Nature Reviews. Cardiology·Martin R Cowie, Miles Fisher
Jan 24, 2020·Frontiers in Cardiovascular Medicine·Yasuhiro Maejima
Oct 4, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Nesrine El-BizriLuiz Belardinelli
Dec 2, 2020·Channels·Kornél KistamásPéter P Nánási
Mar 2, 2021·Frontiers in Cardiovascular Medicine·Qingchun ZengDingli Xu
Jun 3, 2021·International Journal of Molecular Sciences·Stefano MorottiEleonora Grandi
Aug 28, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Antonella CelliniPetra Eder-Negrin

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