PMID: 8611647Jan 17, 1996Paper

Derangement in aerobic and anaerobic energy metabolism in skeletal muscle of critically ill and recovering rats

Biochimica Et Biophysica Acta
Olav RooyackersA J M Wagenmakers

Abstract

As part of our research into the mechanisms of protein wasting and muscle weakness during critical illness, we here investigate various aspects of energy metabolism. Intraperitoneal injection of zymosan in rats leads to an acute phase of critical illness followed by a prolonged recovery phase. Previously we observed low activities of mitochondrial enzymes, reduced protein synthesis rates and low concentrations of glutamine in skeletal muscle of zymosan-treated rats. In the present study we investigated (1) whether decreases in high energy phosphates are present in skeletal muscle of these rats and (2) whether an impairment in the glycolytic pathway or the tricarboxylic acid cycle leads to these decreases. Concentrations of creatine phosphate and ATP were decreased in zymosan-treated rats to approx. 85% of pair-fed control values respectively on day 2 and on days 4 and 6 after treatment. Concentrations of tricarboxylic acid (TCA) cycle intermediates were decreased to 80% on day 6 after zymosan treatment. Lactate/pyruvate ratio and concentrations of lactate and glycogen were normal at all sampling times. We conclude that no major changes in concentrations of high energy phosphates and in concentrations of intermediates of TCA cyc...Continue Reading

References

Oct 1, 1992·Physiology & Behavior·M MuscaritoliM M Meguid
Nov 1, 1991·Metabolism: Clinical and Experimental·U AngeråsJ E Fischer
Aug 1, 1990·Nutrition Reviews·J M Lacey, D W Wilmore
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Aug 1, 1995·European Journal of Clinical Investigation·O E RooyackersA J Wagenmakers
Nov 1, 1994·Clinical Science·O E RooyackersA J Wagenmakers

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Citations

Dec 4, 2012·American Journal of Respiratory and Critical Care Medicine·Jane BattMargaret S Herridge
Sep 12, 2006·FEBS Letters·Ronnie MinnaardMatthijs K C Hesselink
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Katarina FredrikssonOlav Rooyackers
Sep 22, 2007·Critical Care Medicine·Katarina Fredriksson, Olav Rooyackers
Aug 25, 2012·Current Opinion in Critical Care·Claudia C Dos Santos, Jane Batt
Jan 10, 2021·Biology·Francesco BellantiGianluigi Vendemiale

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