Abstract
Anaplastic thyroid cancer arises, or transforms, from pre-existing differentiated thyroid cancer. E-cadherin functions as a cell-cell adhesion molecule that complexes with catenin proteins for function. The objective of this study was to evaluate the change in E-cadherin/beta-catenin expression in the transformation of differentiated to anaplastic thyroid carcinoma. A tissue microarray was constructed from 12 anaplastic thyroid tumors and their adjacent associated differentiated foci. Immunohistochemistry was used to evaluate tumor expression of E-cadherin and beta-catenin. There was decreased expression of E-cadherin and beta-catenin by the anaplastic tumors when compared with the differentiated thyroid tumors from which they evolved. The expression of E-cadherin and beta-catenin was 92% and 67%, respectively, by the differentiated thyroid carcinoma, and 17% and 50%, respectively, by the anaplastic tumors. This report shows that derangement of the E-cadherin/catenin complex is associated with the transformation of differentiated into anaplastic thyroid carcinoma.
References
Jul 15, 1990·Cancer·Y S VenkateshN A Samaan
Jul 15, 1988·Cancer·J ShveroE Kessler
Jul 1, 1997·Surgical Oncology Clinics of North America·P A Treseler, O H Clark
Oct 15, 1998·The Journal of Pathology·A CerratoM Grieco
Aug 18, 1999·World Journal of Surgery·P E VoutilainenA H Sivula
Mar 14, 2000·Annals of Surgery·K Y LamK Y Wan
Mar 13, 2001·Oncogene·C TanS Dedhar
Mar 29, 2001·Journal of Surgical Oncology·A NaitoS Kobayashi
Nov 28, 2001·Clinical and Experimental Dermatology·S Y LeeJ K Koh
Jan 15, 2002·Virchows Archiv : an International Journal of Pathology·E Van AkenM Mareel
Apr 10, 2002·Pathology International·Noriko KatoTeiichi Motoyama
Jul 2, 2002·American Journal of Clinical Pathology·Robin L ParkerC Blake Gilks
Nov 5, 2002·The American Journal of Pathology·Chih Long LiuMatt van de Rijn
Jan 15, 2003·Archives of Otolaryngology--head & Neck Surgery·Sam M WisemanDaniel L Stoler
Jun 6, 2003·Histopathology·A S RochaM Sobrinho-Simões
Jun 26, 2003·Cancer Science·Akira Kikuchi
Jul 29, 2003·Head & Neck·Sam M WisemanDaniel L Stoler
Apr 1, 2004·Biochimica Et Biophysica Acta·Arusha OloumiShoukat Dedhar
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Renaud De CrevoisierMartin Schlumberger
Dec 16, 2004·Langenbeck's Archives of Surgery·Nikola BesicMarija Auersperg
Jan 11, 2005·The Journal of Pathology·Mohammad Ilyas
Jan 15, 2005·Thyroid : Official Journal of the American Thyroid Association·Takeshi KuriharaToshimasa Asahara
Apr 1, 2005·World Journal of Gastroenterology : WJG·Zhi-Hong ZhengKai-Lai Sun
Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E BreceljM Bracko
Aug 12, 2005·Molecular Cancer Therapeutics·Maher N YounesJeffrey N Myers
Citations
Jul 9, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liang LiJost B Jonas
Aug 8, 2009·Irish Journal of Medical Science·J P O'NeillM Walsh
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Darya BuehlerRicardo V Lloyd
May 18, 2010·Thyroid : Official Journal of the American Thyroid Association·Nancy L ChoDaniel T Ruan
Nov 5, 2011·Thyroid : Official Journal of the American Thyroid Association·Jeffrey A Knauf
Feb 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Kazuaki YasuiYuji Nagayama
Jul 9, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Matthew D Ringel
Nov 23, 2006·Annals of Surgical Oncology·Sam M WisemanBlake Gilks
Nov 7, 2008·Endocrine-related Cancer·Robert C SmallridgeJohn A Copland
Aug 7, 2014·International Journal of Endocrinology·Rosalba ParentiGaetano Magro
Apr 16, 2013·Oral Oncology·James Paul O'Neill, Ashok R Shaha
Sep 20, 2011·Molecular and Cellular Endocrinology·Mohsen MalehmirSeyed H Ghaffari
May 7, 2011·American Journal of Surgery·Sam M WisemanSteven J M Jones
Jun 13, 2012·Cancer Biology & Therapy·Juanita J EvansDavid Goldenberg
Dec 3, 2014·Biochemical and Biophysical Research Communications·Si Hyoung KimSeong Jin Lee
Oct 5, 2013·Veterinary Pathology·J L WerbeckT J Rosol
Apr 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J CapdevilaJ Seoane
Mar 6, 2019·Molecular Carcinogenesis·Francesca Maria OrlandellaGiuliana Salvatore
Oct 29, 2018·Histopathology·Jianghua WuBaocun Sun
Aug 16, 2013·Oncology Letters·Simona KellerLorenzo Chiariotti
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Jaime Miguel PitaBranca Maria Cavaco
Oct 18, 2019·The Journal of Pathology·Johan O PaulssonC Christofer Juhlin
Feb 15, 2019·Cell Death & Disease·Shikha SainiBellur S Prabhakar
Mar 23, 2011·Expert Review of Anticancer Therapy·Stefan L KojicSam M Wiseman