PMID: 11933075Apr 5, 2002Paper

Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene

Molecular Carcinogenesis
Montserrat SolanasV Notario

Abstract

The PCPH proto-oncogene was identified by its frequent activation in Syrian hamster fetal cells exposed to 3-methylcholanthrene. We previously isolated human PCPH cDNA and studied its expression in normal human tissues. We report herein the pattern of PCPH expression in normal rat tissues. Each tissue expressed one major PCPH polypeptide that varied in molecular mass in different tissues. Normal mammary gland expressed a single PCPH polypeptide of 27 kDa. This PCPH form also was expressed in lactating mammary glands but at significantly greater levels. These results suggest the existence of tissue-specific regulatory mechanisms for PCPH expression that may be influenced by the differentiation stage. Our previous studies on the involvement of PCPH in human cancer showed that human breast tumor cell lines have frequent alterations in PCPH, including multiple PCPH polypeptide forms that are not expressed in normal cells. These cell lines also have frequent loss of a 27-kDa form identified as the only PCPH polypeptide expressed by normal human breast epithelial cells. In this study, we found that these same alterations occurred in vivo during mammary carcinogenesis in Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene,...Continue Reading

References

Sep 1, 1973·The Journal of Pathology·R K Sharan
Jan 26, 1996·Biochemical and Biophysical Research Communications·M Handa, G Guidotti
Jan 1, 1996·Breast Cancer Research and Treatment·J Russo, I H Russo
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·S C HeffelfingerD Warshawsky
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R G Mehta
Jan 10, 2001·Journal of Mammary Gland Biology and Neoplasia·B A Howard, B A Gusterson
Jan 10, 2001·Journal of Mammary Gland Biology and Neoplasia·P A Masso-WelchM M Ip
Oct 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H SaitoI Tomita

❮ Previous
Next ❯

Citations

Sep 2, 2010·Purinergic Signalling·Mary G O'KeeffeSrdjan M Vlajkovic
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E EscrichL Grau
Nov 15, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Nisha R ParikhAnupam Bishayee
Dec 19, 2002·Molecular Carcinogenesis·María José BlánquezVicente Notario
Jul 22, 2014·BioMed Research International·Paula Andreghetto BraccoMárcia Rosângela Wink
Apr 2, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Montserrat SolanasEduard Escrich
Sep 21, 2007·Molecular Nutrition & Food Research·Eduard EscrichMontserrat Solanas
Jun 3, 2021·Purinergic Signalling·Rafael Paschoal de CamposGuido Lenz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.