Deregulated microRNA species in the plasma and placenta of patients with preeclampsia

Molecular Medicine Reports
Sheng YangFeng Chen

Abstract

Emerging evidence indicates that microRNAs (miRNAs), a class of small non-coding RNAs, are involved in a number of biological processes. The results of SOLiD™ sequencing were used to analyze differentially expressed miRNA profiles in the plasma and placenta of patients with preeclampsia (PE) and a subject who had had a pregnancy without complications. miRNAs were identified that were consistently expressed in the placenta, following normalization of the raw data. miRNAs that had increased and differential expression were selected, as defined by percentage >0.02% and a log2 fold change ≥ |1.2|, respectively. This process was repeated in the plasma. Twenty such miRNAs were identified. These were: miR-126, miR-126*, miR-130a, miR-135b, miR-142-3p, miR-149, miR-188-5p, miR-18a, miR-18b, miR-203, miR-205, miR-224, miR-27a, miR-29a, miR-301a, miR-517c, miR-518-3p, miR-518e, miR-519d and miR-93. These miRNAs belonged to 13 clusters or families. However, only four clusters or families involved two or more of these miRNAs. These were the mir-16 cluster, the mir-17 family, the mir-130 family and the mir-517 family. These abnormally-expressed miRNAs and miRNA gene clusters or families are known to be involved in a number of biological pro...Continue Reading

References

Dec 10, 1998·Nucleic Acids Research·H OgataM Kanehisa
Nov 30, 2000·Journal of Human Hypertension·F Broughton Pipkin, J M Roberts
Feb 24, 2001·Lancet·J M Roberts, D W Cooper
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Vassilis TsatsarisJean-Michel Foidart
Nov 25, 2003·Science·Elsebet LundUlrike Kutay
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Vera Eremina, Susan E Quaggin
May 4, 2004·Current Biology : CB·Dianne S SchwarzPhillip D Zamore
Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Dec 8, 2005·The Journal of Clinical Endocrinology and Metabolism·Marco SciosciaThomas W Rademacher
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Beth L PinelesChong Jai Kim
Nov 10, 2007·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 13, 2008·Developmental Cell·Shusheng WangEric N Olson
Aug 13, 2008·Developmental Cell·Jason E FishDeepak Srivastava
Mar 17, 2009·American Journal of Obstetrics and Gynecology·Xiao-ming ZhuYuan-qing Yao
Jul 16, 2009·Reproductive Biology and Endocrinology : RB&E·Simon GrillOlav Lapaire
Aug 1, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Yali HuYayi Hou
Jan 13, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Francois MouilletYoel Sadovsky
May 11, 2010·American Journal of Obstetrics and Gynecology·Yanqing ZhangYali Hu
Nov 13, 2010·Nucleic Acids Research·Sheng-Da HsuHsien-Da Huang
Nov 26, 2010·American Journal of Obstetrics and Gynecology·Daniel A EnquobahrieMichelle A Williams
Mar 1, 2011·Journal of Reproductive Immunology·Diana M Morales Prieto, Udo R Markert
Jun 24, 2011·PloS One·Matthew A MaccaniCarmen J Marsit
Jun 20, 2012·Molecular Medicine Reports·Levente LázárJános Rigó

❮ Previous
Next ❯

Citations

Nov 22, 2017·Clinical and Experimental Hypertension : CHE·Mahnaz RezaeiSaeedeh Salimi
Jan 31, 2018·Clinical and Experimental Hypertension : CHE·Olive P KhaliqIrene Mackraj
Mar 12, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Antonio Simone LaganàRosario D'Anna
May 4, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Z MohseniC Ghossein-Doha
Oct 17, 2018·Epigenomics·Sylvia E BadonDaniel A Enquobahrie
Feb 1, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eric DevorMark Santillan
Jul 3, 2019·Molecular Biology Reports·Saeedeh SalimiMinoo Yaghmaei
Oct 10, 2019·Journal of Cellular Physiology·Maryam HemmatzadehMehdi Yousefi
Aug 27, 2016·Clinical Science·Jeanie B TryggestadSteven D Chernausek
Oct 20, 2019·Journal of Clinical Laboratory Analysis·Luyan ZhangGuomei Cao
Aug 5, 2015·Endocrinology·Cheryl S Rosenfeld
Apr 17, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Heng YangShiyao Xiao
Oct 25, 2017·Current Hypertension Reports·Ross McNallyLana McClements
Mar 6, 2019·Life Science Alliance·Alexander M TsengUNKNOWN Collaborative Initiative on Fetal Alcohol Spectrum Disorders
Apr 30, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Gui-Mei WuJi-Yun Li
May 22, 2020·Frontiers in Genetics·Sudipta DuttaDouglas M Ruden
Dec 15, 2016·Frontiers in Medicine·Douglas B Kell, Louise C Kenny
Oct 19, 2016·American Journal of Reproductive Immunology : AJRI·Yuping WangLynn J Groome
Jan 16, 2020·International Journal of Molecular Sciences·Katrien SmitsAnn Van Soom
May 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Berta Mas-ParésJudit Bassols
Oct 6, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Elizabeth M KennedyCarmen J Marsit
Nov 25, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Utku AkgörFiliz Çayan
Jul 30, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Caterina LiciniDaniela Marzioni
Feb 24, 2020·Theriogenology·Carmen Almiñana, Stefan Bauersachs
Mar 12, 2021·The Journal of Obstetrics and Gynaecology Research·Beibei LiuTiantian Wang
Mar 19, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Caitlin G HoweCarrie V Breton
May 18, 2021·Frontiers in Physiology·Ailing ChenYing Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Thomas TemplinLubomir B Smilenov
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jeong-Won LeeDuk-Soo Bae
© 2022 Meta ULC. All rights reserved