Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis

Oncogene
K A HoneycuttJ M Shohet

Abstract

Minichromosomal maintenance protein 7 (MCM7) is an essential component of the replication helicase complex (MCM2-7) required for DNA replication. Although this function is highly conserved among eukaryotes, additional functions for the MCM molecules continue to be described. Minichromosomal maintenance protein 7 is a marker for proliferation and is upregulated in a variety of tumors including neuroblastoma, prostate, cervical and hypopharyngeal carcinomas. To further investigate the general role of MCM7 in tumorigenesis, we generated a mouse model with deregulated MCM7 expression targeted to the basal layer of the epidermis using the keratin 14 (K14) promoter (K14.MCM7). When subjected to a two-stage chemical carcinogenesis protocol (dimethylbenz[alpha]anthracene (DMBA) initiation with 12-ortho-tetradecanoylphorbol-13-acetate promotion), K14.MCM7 mice showed significantly increased incidence and prevalence of tumor development relative to controls. Furthermore, within 40 weeks of treatment over 45% K14.MCM7 mice exhibited tumors that had converted to squamous cell carcinomas versus none in the control group. As predicted from previous skin carcinogenesis studies using DMBA as the initiating agent, Ras mutations where found in m...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A NelsonG T Bowden
Jan 1, 1992·Pharmacology & Therapeutics·J DiGiovanni
Jan 1, 1988·Advances in Cancer Research·S H Yuspa, M C Poirier
Jan 1, 1982·Carcinogenesis·L K AshmanI Kotlarski
Jan 1, 1993·Molecular Carcinogenesis·J C Barrett, M Anderson
Aug 26, 1998·Biochemical and Biophysical Research Communications·I KukimotoT Kanda
Jun 29, 2000·Annual Review of Biochemistry·B K Tye
Mar 10, 2001·Journal of Dairy Science·T M SchmitL W Tauer
May 31, 2001·Nature Genetics·R L WaikelD R Roop
Aug 21, 2001·Genes & Development·R N Eisenman
Apr 16, 2003·Genes & Development·Paula C FernandezBruno Amati
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Susan L Forsburg
Jun 17, 2004·British Journal of Cancer·S B WhartonG H Williams
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Bik K Tye, Victoria K Chang
Sep 29, 2004·Journal of Clinical Pathology·V PadmanabhanB G Beatty
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Robert GrützmannHans Detlev Saeger

❮ Previous
Next ❯

Citations

Mar 26, 2013·Journal of Molecular Neuroscience : MN·Jiajia ChenZhiming Cui
Nov 17, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heba W Z KhellaGeorge M Yousef
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Naoki NitaniTakuro Nakagawa
Sep 20, 2008·The Journal of Biological Chemistry·Diane M KanterDaniel L Kaplan
Dec 1, 2007·Carcinogenesis·Luis R Borlado, Juan Méndez
Jun 7, 2012·Journal of Biochemistry·Emi WatanabeYukio Ishimi
Oct 11, 2011·Nucleic Acids Research·June Sanchez-BerrondoGuillermo Montoya
Apr 10, 2009·Plant Physiology·Randall W ShultzLinda Hanley-Bowdoin
Sep 24, 2010·BMC Biochemistry·Xiaoli MaMegan J Davey
Nov 19, 2008·BMC Research Notes·Patricia SeverinoUNKNOWN Head and Neck Genome Project GENCAPO
May 24, 2011·World Journal of Clinical Oncology·Jian-Hua Luo
Sep 23, 2014·BioMed Research International·Nicholas E Simon, Anthony Schwacha
Sep 27, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dimitrios KaraviasVasiliki Bravou
Dec 15, 2010·Acta histochemica·Sarah E HensonCindy S Malone
Jan 16, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shinji FujiokaHisao Ito
Nov 8, 2008·The American Journal of Pathology·Yi-Kang ShiJian-Hua Luo
Nov 23, 2007·Current Opinion in Cell Biology·Gareth H Williams, Kai Stoeber
Dec 22, 2009·Molecular BioSystems·Ran Brosh, Varda Rotter
Jan 22, 2009·Genes, Chromosomes & Cancer·Francesca DemichelisMark A Rubin
Feb 21, 2008·Journal of Cellular Biochemistry·Deborah H CharychAnnette O Walter
Aug 9, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hong-Ying ChenXiao-Zhong Wang
Dec 3, 2011·Journal of Cellular Biochemistry·Domenic Di Paola, Maria Zannis-Hadjopoulos
Nov 14, 2012·Molecular Nutrition & Food Research·Mark J McCannNicole C Roy
Oct 13, 2011·The Journal of Pathology·Gareth H Williams, Kai Stoeber
Jul 13, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Yan-Ming ZhouZheng-Feng Yin
Jan 21, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Yusuke GotoNaohiko Seki
Feb 21, 2008·Biochemical and Biophysical Research Communications·Yoshikazu JohmuraMasayoshi Imagawa
Sep 5, 2013·Bioscience Reports·Nicholas SimonAnthony Schwacha
Mar 20, 2014·Seminars in Cell & Developmental Biology·S Champeris TsanirasS Taraviras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Annual Review of Biochemistry
B K Tye
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Arjen KoppenLinda J Valentijn
© 2021 Meta ULC. All rights reserved