Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus

Nature Medicine
H LeeJ U Jung

Abstract

At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma herpesviruses, K1 and STP exhibit no similarity in amino acid sequence or in structural organization. Since STP is required for the oncogenic potential of HVS, we investigated the functional consequence of K1 expression. Expression of the K1 gene in rodent fibroblasts produced morphologic changes and focus formation indicative of transformation. A recombinant herpesvirus in which the STP oncogene of HVS was replaced with K1, immortalized primary T lymphocytes to IL-2 independent growth and induced lymphoma in common marmosets. These results demonstrate the transforming potential of the K1 gene of KSHV.

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J U JungR C Desrosiers
May 1, 1984·Journal of Virology·J M KoomeyR C Desrosiers
May 1, 1995·Current Biology : CB·D Ganem
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Mar 25, 1995·Lancet·Y Q HuangA E Friedman-Kien
Sep 15, 1994·Nature·T P MäkeläR A Weinberg
Dec 1, 1995·Molecular and Cellular Biology·J U Jung, R C Desrosiers
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·W ZhongD Ganem
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S M DuboiseJ U Jung
Oct 1, 1996·Journal of Clinical Microbiology·C C MarchioliB J Poiesz
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J RussoP S Moore
Jan 1, 1997·Journal of Virology·F NeipelB Fleckenstein
Mar 1, 1997·Journal of Virology·M LiJ U Jung
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·K M IzumiE D Kieff
Jan 28, 1998·Journal of Virology·S M DuboiseJ U Jung

❮ Previous
Next ❯

Citations

Aug 21, 2003·Journal of Biomedical Science·John Nicholas
Jun 26, 1999·Medical Oncology·G GaidanoP Biberfeld
Jul 26, 2003·Folia Microbiologica·J Rajcáni, M Kúdelová
Oct 19, 2007·Archives of Virology·N CloutierL Flamand
Aug 11, 2005·Current Oncology Reports·Emily L Wong, Blossom Damania
Apr 19, 2002·Biochimica Et Biophysica Acta·Richard G Jenner, Chris Boshoff
Oct 12, 2000·Clinics in Dermatology·P Whelan, D T Scadden
Jun 19, 2001·Current Opinion in Immunology·L Matsuuchi, M R Gold
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M CattelanL Chieco-Bianchi
Mar 9, 1999·Trends in Microbiology·N L Ross
Jun 4, 1999·Trends in Microbiology·T F Schulz, P S Moore
Jul 8, 2000·Microbes and Infection·H GruffatE Manet
Apr 28, 2001·Cytokine & Growth Factor Reviews·J ChoiJ U Jung
Apr 18, 1998·Nature Medicine·D T Scadden
Nov 26, 2010·Nature Reviews. Cancer·Patrick S Moore, Yuan Chang
Mar 25, 2006·Nature Reviews. Immunology·John G Monroe
Jul 21, 2004·Nature Reviews. Microbiology·Blossom Damania
Mar 18, 1999·Pathology Oncology Research : POR·G MikalaI Vályi-Nagy
Apr 6, 2000·The New England Journal of Medicine·K Antman, Y Chang
Dec 13, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J C LeaoC Scully
Jan 9, 2009·The Journal of Biological Chemistry·Effi WiesFrank Neipel
Dec 8, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xiaohui BiBetsy J Barnes
Sep 2, 1999·Journal of the National Cancer Institute·M S ReitzR C Gallo
Oct 21, 1999·Journal of the National Cancer Institute·G S Hayward
Oct 3, 1999·Current Opinion in Oncology·E Cesarman, E A Mesri
Jul 14, 2000·AIDS·D J BlackbournJ A Levy
Mar 3, 2006·Southern Medical Journal·Peter H Wiernik, Polly R Etkind
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J McGeoch
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P S Moore, Y Chang
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Fickenscher, B Fleckenstein
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Damania, R C Desrosiers
Jul 5, 2002·Clinical Microbiology Reviews·Dharam V AblashiEthel Cesarman

❮ Previous
Next ❯

Related Concepts