Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.

Experimental and Molecular Pathology
Marcela Cristina S RobainaClaudete Esteves Klumb

Abstract

Methylation of CpG islands in promoter gene regions is frequently observed in lymphomas. DNA methylation is established by DNA methyltransferases (DNMTs). DNMT1 maintains methylation patterns, while DNMT3A and DNMT3B are critical for de novo DNA methylation. Little is known about the expression of DNMTs in lymphomas. DNMT3A and 3B genes can be regulated post-transcriptionally by miR-29 family. Here, we demonstrated for the first time the overexpression of DNMT1 and DNMT3B in Burkitt lymphoma (BL) tumor samples (69% and 86%, respectively). Specifically, the treatment of two BL cell lines with the DNMT inhibitor 5-aza-dC decreased DNMT1 and DNMT3B protein levels and inhibited cell growth. Additionally, miR-29a, miR-29b and miR-29c levels were significantly decreased in the BL tumor samples. Besides, the ectopic expression of miR-29a, miR-29b and miR-29c reduced the DNMT3B expression and miR-29a and miR-29b lead to increase of p16(INK4a) mRNA expression. Altogether, our data suggest that deregulation of DNMT1, DNMT3B and miR29 may be involved in BL pathogenesis.

References

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R TaubP Leder
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Aug 23, 2002·Seminars in Cancer Biology·Mikael S Lindström, Klas G Wiman
May 2, 2003·Annals of the New York Academy of Sciences·Timothy H Bestor
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Claudete Esteves KlumbRaquel Ciuvalschi Maia
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jordan M CumminsVictor E Velculescu
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Dec 11, 2007·Nature Genetics·Laura PasqualucciRiccardo Dalla-Favera
Dec 11, 2007·Nature Genetics·Tsung-Cheng ChangJoshua T Mendell
Jun 10, 2008·Current Opinion in Hematology·Ramiro Garzon, Carlo M Croce
May 28, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katsuhiko NoshoShuji Ogino
Sep 12, 2009·European Journal of Haematology·Diamantina VasilatouJohn Dervenoulas
Oct 6, 2009·Nature Genetics·Ann-Marie BröskeFrank Rosenbauer
Oct 24, 2009·Blood·Ramiro GarzonCarlo M Croce
Mar 25, 2010·British Journal of Haematology·Jan-Lukas RobertusAnke van den Berg
Oct 1, 2010·Genes & Cancer·Thi V Bui, Joshua T Mendell
Nov 12, 2010·The New England Journal of Medicine·Timothy J LeyRichard K Wilson
Nov 18, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Tung NguyenDave S B Hoon
Jan 19, 2011·Chembiochem : a European Journal of Chemical Biology·Renata Zofia JurkowskaAlbert Jeltsch
Apr 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kathrin MutzeGisela Keller
Apr 12, 2011·Blood·María J BuenoMarcos Malumbres
May 27, 2011·Genome Research·Agustin F FernandezManel Esteller
Jun 11, 2011·EMBO Reports·Hélène DenisFrançois Fuks
Jan 6, 2012·The New England Journal of Medicine·Lucile CouronnéOlivier A Bernard
Apr 3, 2012·Cell·Chi V Dang
May 30, 2012·Nature Reviews. Genetics·Peter A Jones
Jul 5, 2012·Blood·Lorena Di LisioMiguel A Piris
Aug 18, 2012·Cancer Cell·Sandrine SanderKlaus Rajewsky
Oct 2, 2012·Cell·Charles Y LinRichard A Young
Jan 30, 2013·European Journal of Cell Biology·Yang WangXiubao Ren
Mar 20, 2013·Seminars in Hematology·Keqin Kathy LiSai-Juan Chen

❮ Previous
Next ❯

Citations

Oct 11, 2015·BMC Cancer·Giulia De FalcoPier Paolo Piccaluga
May 31, 2016·Biochemical and Biophysical Research Communications·Haizhou Yu, Weixi Yang
Sep 15, 2016·PloS One·Martha L SlatteryLila E Mullany
Aug 12, 2017·American Journal of Respiratory Cell and Molecular Biology·Ting XieDianhua Jiang
Aug 17, 2018·Current Hematologic Malignancy Reports·Jennifer K Lue, Jennifer E Amengual
Aug 8, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea Di Pietro, Kim L Good-Jacobson
Apr 6, 2019·Journal of Cellular Physiology·Mohsen AlizadehBehzad Baradaran
Jul 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ZengXiaofang Che
Nov 7, 2019·Cells·Marcela Cristina RobainaClaudete Esteves Klumb
Jan 11, 2018·Journal of Cancer Research and Clinical Oncology·Luciano MazzoccoliClaudete Esteves Klumb
May 3, 2016·British Journal of Haematology·Mitchell S Cairo, Ross Pinkerton
Oct 24, 2018·Biomarker Insights·Carla SoléCharles H Lawrie
Oct 18, 2016·Oncology Reports·Yuan-Yuan ZhangJian-Zhen Shen
Apr 13, 2018·Reproductive Sciences·Tsai-Der Chuang, Omid Khorram
Nov 5, 2019·Frontiers in Genetics·Marcelo L RibeiroGaël Roué
Mar 7, 2019·Nature Reviews. Clinical Oncology·David SermerAnas Younes
May 21, 2019·Biomarker Insights·Kah Keng WongTina M Green
Sep 12, 2018·International Journal of Molecular Sciences·Jaqueline Carvalho de OliveiraMaría Sol Brassesco
Oct 21, 2020·Clinical Epigenetics·Min Yue ZhangChor Sang Chim
Mar 22, 2021·Life Sciences·Yang LiuChaolai Man
Feb 20, 2018·The American Journal of Pathology·Agnieszka Dzikiewicz-KrawczykAnke van den Berg
Nov 25, 2020·Blood Reviews·Alain CheblyEdith Chevret

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.